[22.] Abisheva NN, Beduleva LV, Menshikov IV, Ivanov VV (2010) Investigation of the mechanisms on idiotype
regulation of the immune response in the experimental model of autoimmune hemolytic anemia in mice.
However, if the genotypes change drastically, as by introduction of a new idiotype
, a new assessment of mega-environments is needed.
In that paper, the researchers claimed that a foreign gene inserted into mice generally was not expressed, but somehow influenced comparable mouse genes to produce "copycat" antibodies carrying the chemical signature (idiotype
) of the inserted gene (SN: 3/31/90, p.200).
These antibodies may directly bind to the idiotype
of the drug or to other sites in its proximity, eliciting steric hindrance that, in turn, prevents binding of the drug to TNF.
When the researchers examined immune-system cells from the transgenic mice, they found large amounts of a type of antibody displaying the characteristic chemical signature, or idiotype
, of the foreign gene.
Reinl et al., "Plant-produced idiotype
vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical study," Proceedings of the National Academy of Sciences, vol.
Expression of VHIII-associated cross-reactive idiotype
on human B lymphocytes.
Specificity and idiotype
expression of IgM produced by CD5+ and CD5- cord blood B cells.
This high anti-P3 idiotype
antibody response might be part of a protection mechanism to block self-reactive antibodies.
recognizes portions of disease organisms or cancer cells that can be thought of as sticking out from those objects like hands.
' cascade provides an antibody that could be a substitute for the original antigen," Kohler says.
Bayer's personalised idiotype
vaccine for the treatment of Non-Hodgkin's-Lymphoma (NHL) is currently in Phase I clinical trials, and the cooperation is related to the development of a personalised Non-Hodgkin's-Lymphoma vaccine.