idiotype


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Related to idiotype: isotype, allotype

idiotype

[′id·ē·ə‚tīp]
(immunology)
The unique amino acid sequence and corresponding three-dimensional structure of the variable region of an immunoglobulin molecule that determines its antigenic specificity.
References in periodicals archive ?
2003) Idiotype - antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
However, if the genotypes change drastically, as by introduction of a new idiotype, a new assessment of mega-environments is needed.
Neutralizing ADAs block the idiotype of the drug molecule directly or by steric hindrance, with sufficient strength to interfere with, or eliminate, the activity of the drug.
Instead, they reported that the foreign gene was not turned on in most of the cells, but rather it had somehow influenced the mouse's own genes to mimic the foreign gene's idiotype.
Idiotypes can provoke anti-idiotypes, which in turn can provoke anti-idiotypes that attach to the initial provoker as well as to the anti-idiotype.
Bayer's personalised idiotype vaccine for the treatment of Non-Hodgkin's-Lymphoma (NHL) is currently in Phase I clinical trials, and the cooperation is related to the development of a personalised Non-Hodgkin's-Lymphoma vaccine.
Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens.
We hypothesize that the interfering antibody in the Olympus ferritin assay is a natural antiidiotypic antibody that binds to a unique idiotype on the rabbit antihuman ferritin antibody linked to latex (5).