idiotype

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idiotype

[′id·ē·ə‚tīp]
(immunology)
The unique amino acid sequence and corresponding three-dimensional structure of the variable region of an immunoglobulin molecule that determines its antigenic specificity.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In order to elucidate which B cell populations were participating in the anti-P3 idiotype response, BALB/Xid mice were immunized with P3 mAb.
Urbain, "Assessment of a functional role of auto-anti-idiotypes in idiotype dominance," European Journal of Immunology, vol.
Routsias, "Idiotype, anti-idiotype network of autoantibodies: pathogenetic considerations and clinical application," Autoimmunity Reviews, vol.
MHC class I-restricted CTL recognizes the processed form(s) of idiotype," Cellular Immunology, vol.
Eisen, "Immune responses of BALB/c mice to the idiotype of T15 and of other myeloma proteins of BALB/c origin: implications for an immune network and antibody multispecificity," Cold Spring Harbor Symposia on Quantitative Biology, vol.
Fujimoto, "Cytotoxic T lymphocyte clone recognizing self idiotype: its regulatory role in antibody production," European Journal of Immunology, vol.
Immunization with isologous idiotype induces auto-anti-idiotypic antibodies and suppresses the autoantibody response elicited by antigen: a serologic and cellular analysis," Journal of Immunology, vol.
(2006) Expression of functionally active scFv fragment of idiotype antibodies with beta lactamase activity.
But now compare the idiotype represented by hypothetical Genotype A.
However, if the genotypes change drastically, as by introduction of a new idiotype, a new assessment of mega-environments is needed.
The idiotype recognizes portions of disease organisms or cancer cells that can be thought of as sticking out from those objects like hands.