idiotype

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idiotype

[′id·ē·ə‚tīp]
(immunology)
The unique amino acid sequence and corresponding three-dimensional structure of the variable region of an immunoglobulin molecule that determines its antigenic specificity.
References in periodicals archive ?
Lemke H, Tanasa RI, Trad A, Lange H (2012) Function of maternal idiotypic and anti-idiotypic antibodies as transgenerational messengers.
Idiotypic Immune Networks in Mobile-Robot Control, IEEE Transactions on Systems, Man and Cybernetics, Part B: Cybernetics, Vol.
Their underlying data, she said, did not support their conclusion of idiotypic mimicry.
1986) Idiotypic determinants of monoclonal antibodies that bind to 3-fucosyllactosamine.
Self organization: the memory cells are organized into so-called idiotypic network (a hypotheses stated by Jerne, 1974) that changes in time.
AltaRex has granted to Biomira a royalty-free, non-exclusive license, if and when this patent issues, in relation to antigen-based or idiotypic cancer vaccines.
It has been postulated that heterophilic antibodies may arise through immunization via the gastrointestinal tract or that they play a role in regulation of the immune system via idiotypic network interactions (2,10).
Genzyme Transgenics is also developing idiotypic vaccines in collaboration with the National Cancer Institute.
Therefore, the interfering antibodies might be idiotypic antibodies that bind to a unique idiotype present on the Elecsys anti-TSH antibodies but not on the Centaur and Architect antibodies.
However, an interference assay will detect not only human antibodies against relevant isotypic and idiotypic epitopes shared by both assay antibodies, but also irrelevant human antibodies against idiotypic epitopes unique to the single antibody used as both capture and tracer antibody (21).
The finding that the prolactin concentration measured by the VIDAS decreased after treatment with the HBT blocking agent supports the hypothesis that the interfering antibody was an IgM, an idiotypic antibody that binds to a unique idiotype on the VIDAS antibodies.
For example, if the capture, detection, and infused antibodies are identical, then the assay will detect isotypic and idiotypic HAMAs.