To gain more insight into which structural features of nitensidine A contribute to its ability to serve as a substrate for ABCB1, the role of the imino
nitrogen atom was examined with a focus on its biological activities.
Its research is focussed on the properties of imino
sugars, naturally occurring compounds found in minute quantities in certain plants.
sugar derivatives: These compounds may work by targeting the formation and proper folding of HCV envelope proteins, or through inhibiting ion channel formation and possibly preventing the release of new virus from infected cells.
Highly enantioselective imino
pinacol coupling leading to the synthesis of 1,2-diphenylethylenediamine derivatives.
Macrophage cytotoxicity: Role for L-Arginine deiminase and imino
nitrogen oxidation to nitrite.
Methylated melamine resins Highly methylated melamine resins High imino
melamine resins Partially methylated melamine resins
Monodentate Schiff bases are not known to form stable complexes, probably due to the insufficient basic strength of imino
nitrogen of the C = N group.
MNLpharma ('MNL') is a UK drug discovery and development company exploiting imino
sugar therapeutics for the prevention and treatment of disease.
Periodate oxidation of polysaccharides offers a convenient route to synthesize polymer-drug conjugates especially with drugs possessing aliphatic amino functions via imino
bonds with the aldehyde groups of the oxidized polysaccharide.
The non-tannin fraction contains phenolic compounds (monomeric flavonoid compounds and hydroxycinnamic acid derivatives), carbohydrates (glucose, fructose, saccharose and hydrocolloidal gums) and nitrogen compounds (such as amino and imino
The surface skin cells contain free amino, hydroxy, sufhydryl, carboxy, imino
, and similar chemically reactive moieties in their protein and nucleic acid components that can be chemically attached, via a covalent chemical bond, to a cosmetic or drug molecule using an appropriate bonding agent attached to the drug or cosmetic ingredient (see figure).
6] SO, has a distorted square pyramidal coordination geometry about Cu(II) with one pyridine N atom, the S atom and the imino
N atom from the thiosemicarbazone ligand, together with the N atom from an isothiocynato ligand, in the basal plane.