(7) Marcher's dreaming for immortalization
masquerades as a self-effacing negation in the story: "It wasn't a thing of a monstrous order; not a fate rare and distinguished; not a stroke of fortune that overwhelmed and immortalised; it had only the stamp of the common doom.
Classification of mutations found in hematological malignancies Class I mutations (induce proliferation or inhibit apoptosis) FLT3-ITD, cKit, PDGFR, TEL-PDGFR, FGFR JAK2, JAK3, Bcr-Abl N-Ras, K-Ras p53, NF1 Class II mutations (inhibit differentiation or induce immortalization
) Runx 1/AML1, PU1, C/EBP[alpha] MLL fusions, PML-RA[R.sub.,] AM[LAMBDA]1--ETO Table 2.
Inactivation of p16INK4a, with retention of pRB and p53/ p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization
. J Biol Chem 279(42):43634-43645.
Integration frequently disrupts HPV E2 (E2 regulatory protein) gene expression, leading to increases in E6 and E7 viral oncoproteins, which in turn promote cellular immortalization
Aristotle uses the word immortalization
(to athanatizein, 2001, Nicomachean Ethics, X.vii.8) to describe the activity of the intellectus in relation to what is perfect or best (the Ariston); today, however, the significance of the intellectus and its contemplative activity has been drastically diminished (if not entirely forgotten) in favour of exclusive attention to the discursive skills of the ratio--a fact not lost on contemporary contemplative writers on education like Laurence Freeman (Freeman, 2012, p.
This strategy of reflection and instrumentalization, of turning the passive and captive beauty of poetry into an active tool of immortalization
and political statement, suggests Petrarch's conception of the real political power of poetry.
Chapters address topics such as the biology and genetics of cells and organisms; the nature of cancer; tumor viruses; cellular oncogenes; growth factors, receptors, and cancer; cytoplasmic signaling circuitry; tumor suppressor genes; control of the cell cycle clock; apoptosis; cell immortalization
and tumorigenesis; maintenance of genomic integrity and the development of cancer; heterotypic interactions and the biology of angiogenesis; tumor immunology and immunotherapy; and recently developed therapies.
Who merits immortalization
for this momentous event?
Bad Graffiti lives up to its title as a full-color, photographic immortalization
of some of the most vulgar, coarse, silly, or even obscene spray-painted vandalism to be unceremoniously discovered.
Endogenous oxidative stress prevents telomerase-dependent immortalization
of human endothelial cells.
Latent proteins which promote B cell immortalization
include EBNA-1, EBNA2, EBNA-3A, EBNA-3C, EBNA-LP, and LMP-1.
Individual factors as discussed previously may also influence perspectives of acceptability toward providing genetic samples for immortalization
. However, given the dearth of research on perspectives toward immortalizing genetic samples among this population, one respondent suggested this is a topic of interest to explore.