globulin

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globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
Therefore, most of them will receive a routine, but unnecessary, antenatal injection of Rh immune globulin if pregnant and a second injection of Rh immune globulin postpartum if they deliver an Rh-positive newborn.
The standard agent for prophylaxis after exposure to the hepatitis A virus has been immune globulin 0.02 mL/kg, administered intramuscularly.
Clinical hepatitis A was diagnosed in 3.5% of those given the vaccine and 2.7% of those given immune globulin (relative risk=1.32; 95% CI, 0.69-2.5).
Experience with the use of an investigational F(ab')2 heptavalent bolulism immune globulin of equine origin during an outbreak of Type E botulism in Egypt.
Anaphylactic reactions rarely occur with immune globulin products, except in IgA-deficient patients that receive a product containing significant amounts of IgA.
Family members and other intimate contacts must be advised to seek medical advice about immune globulin shots or vaccination.
-- Diplomat Specialty Pharmacy last month filed for a $100 million initial public offering and acquired MedPro Rx Inc., which is focused on specialty infusion therapies, including immune globulin.
The first 2 sentences should have read as, "An analysis of responses to the supplemental questions in the College of American Pathologists (CAP) proficiency testing for the Fetal RBC Detection Survey (HBF-A 2007 Survey) revealed that 20.7% of participants who used the method of the AABB Technical Manual (1) to calculate the postpartum dose of Rh immune globulin (Rhlg) would have recommended an inaccurate dose.
By using a rabies vaccine and human rabies immune globulin (hRIG) soon after exposure, patients are protected from the fatal disease.

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