immunization


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immunization:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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; vaccinationvaccination,
means of producing immunity against pathogens, such as viruses and bacteria, by the introduction of live, killed, or altered antigens that stimulate the body to produce antibodies against more dangerous forms.
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Immunization

 

a method of creating artificial immunity in man and animals. Active and passive immunization are distinguished.

Active immunization involves injecting antigens into the body. The commonest form of active immunization is vaccination—that is, the use of vaccines, preparations obtained from microorganisms (bacteria, rickettsias, and viruses) or their metabolic products (toxins) for the specific prevention of infectious diseases in man and animals. Active immunization is produced by applying a preparation (for example, a vaccine) to the skin, by injecting it subcutaneously, intracutaneously, intramuscularly, intraperitoneally, or intravenously, or by administering it orally or by inhalation. The dose of the vaccine influences the efficacy of immunization (to a certain limit, the immunizing effect increases with increasing dosage; hence, optimum doses, determined experimentally, are used). The immunization schedule, the reactivity of the organism, and the quality of the preparation are important factors.

The antigen is usually injected several times to create immunity. A second immunization (reimmunization) is carried out no sooner than one or two weeks after the first, so that the antibodies and antibody-forming cells will not be neutralized by excess antigen and thereby reduce the strength of the growing immunity. Immunizations repeated at intervals of several months or years are very effective.

Antigens adsorbed on aluminum hydroxide, phosphates, or alums or mixed with mineral oils are frequently used for purposes of immunization. These substances, called adjuvants, intensify the immunizing effect of the antigen, bring about its gradual absorption from the injection site, and stimulate nonspecific antibody formation. Active immunization produces prolonged immunity (for a year or more) through the formation of specific antibodies and immune cells, and through the stimulation of nonspecific immunity factors.

Passive immunization is produced by injecting serum or serum fractions from the blood of immune animals and persons subcutaneously, intramuscularly, or, in certain emergencies, intravenously. Such preparations contain preformed antibodies, which neutralize toxin, inactivate the causative agent, and prevent the agent from spreading. Passive immunization creates temporary immunity (to a month). It is used to prevent disease in cases of contact with a source of infection (measles, diphtheria, tetanus, gas gangrene, plague, anthrax, influenza [seroprophylaxis] or, if the disease has already set in, to mitigate its course [serotherapy]). Sometimes combined immunization is used: first the immune serum is injected to help the patient cope with the infection, and then the vaccine is introduced in order to create a more stable immunity.

Homologous serums (that is, serums obtained from human blood) are preferred for the seroprophylaxis of infections in man. These serums generally do not provoke allergic reactions and are effective in infections (measles, infectious hepatitis) for which appropriate serums cannot be obtained from animals. Heterologous serums, or those obtained from animals (horse serum is used most frequently), may cause sensitization and provoke allergic reactions (anaphylactic shock, serum sickness). The use of heterologous serums is being curtailed. Seroprophylaxis with protein fractions (gamma globulin, polyglobulin and so forth) of human venous, placental, and abortion blood is commonly used instead.

Immunization is widely used against animal diseases caused by pathogenic viruses (foot-and-mouth disease, cattle plague), rickettsias (hydropericarditis), and bacteria (anthrax, blackleg, brucellosis). It is carried out in a planned regime, with account taken of the local conditions and the particular characteristics of the diseases.

A. KH. KANCHURIN and N. V. MEDUNITSYN

immunization

[‚im·yə·nə′zā·shən]
(immunology)
Rendering an organism immune to a specific communicable disease.
References in periodicals archive ?
He said that routine immunization of children up to 15 months is essential to control infant mortality rate in the country and said that this centre will protect many children from carrying fatal disease by providing free immunization cover.
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Martin IG et al reported that Objective Structured Clinical Examination (OSCE) played a key role in imparting the psychomotor skills among the medical students to administer vaccines as well as communicate to the parents regarding the adverse events following Immunization. [9] The introduction of specific teaching and learning modalities and core competencies regarding Immunization may effectively address the issue of boosting the confidence among the medical students to improve their quality of own personal awareness and ability to educate the patients also.
Accordingly, he said the government came up with several initiatives to address some of the challenges such as the establishment of National Emergency Routine Immunization Center (NERIC) which primarily aims to revamp the country's Routine Immunization (RI) Programme.
* Check immunization records with every healthcare visit.
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The United States Advisory Committee on Immunization Practices (ACIP), the American Academy of Pediatrics, and the American Academy of Family Physicians recommend a specific immunization schedule each year.
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