(d) HE (left) and human-specific vimentin staining of cell line 1-17 transplanted into immunodeficient
Yang, "Reconstitution of a functional human immune system in immunodeficient
mice through combined human fetal thymus/liver and CD[34.sup.+] cell transplantation," Blood, vol.
Serotype 2 iVDPV has been the most prevalent serotype detected in immunodeficient
patients (64%), followed by serotypes 1 (21%) and 3 (15%) (18): our series showed similar findings.
The histological structure of the tissue and cells of the investigated PDX models were similar when implanted subcutaneously in humanized or immunodeficient
mice, and still closely resembled the patient donor material.
A recombinant vaccine would be far less sensitive to temperature and would not require immunodeficient
mice in the manufacturing process, thereby making the finished product much more cost effective and practical for on-ranch use.
Testicular tissue grafting into immunodeficient
mice has become an interesting and promising scientific tool for the generation of gametes and the study of testicular function.
Travnicek, "The severe combined immunodeficient
mouse as a model for Encephalitozoon cuniculi microsporidiosis," Folia Parasitologica, vol.
(12,26,27) When sorted by flow cytometry, tumor cells expressing the above molecules were more tumorigenic when transplanted into immunodeficient
mice than were all of the other types of cells in the tumor.
* A normal Ga-67 scan of the chest of an immunodeficient
patient excludes infection with a high degree of certainty.
To demonstrate clinical potential of ciPSCs to treat models of injury, we generated endothelial cells (ciPSC-ECs) and used these cells to treat immunodeficient
murine models of myocardial infarction and hindlimb ischemia.
Among the topics are the breakdown in peripheral tolerance in type 1 diabetes (T1D) in mice and humans, humoral autoimmunity immunologic and metabolic biomarkers of beta-cell destruction in the diagnosis of T1D, the hygiene hypothesis to explain the increasing frequency of insulin-dependent diabetes, advancing animal models of human T1D by grafting functional human tissues in immunodeficient
mice, and clinical immunologic interventions.