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Diagnosis based upon the reaction of blood serum of a patient.



a method of identifying a disease affecting man, animals, or plants based on the ability of blood-serum antibodies specifically to react with the corresponding antigens.

In medicine, serodiagnosis is used in diagnosing infectious and certain noninfectious diseases, using such methods as immunofluorescence. Antigens in tissue and such biological fluids as blood and urea are detected by means of complement fixation reaction and the retardation of passive hemagglutination, which are used in the serodiagnosis. Serodiagnosis is also used in the determination of bacterial and viral types isolated from diseased individuals and in the establishment of the specific relationships between proteins and human blood groups with the aid of specific serums. Another serodiagnostic method involves the recording of the characteristic changes in blood serum that occur as a result of the action of certain nonspecific reagents, for example, the sedimentation reactions with lipids during syphilis and the gelatinization of serum caused by formaldehyde during leishmaniasis.


In veterinary medicine, serodiagnosis is used in the mass diagnosis of infectious animal diseases. It allows a disease to be diagnosed prior to the manifestation of clinical symptoms. Depending on the substance being studied and the suspected disease, various reactions can be used, including agglutination, precipitation, and complement fixation; the reactions are often combined with allergic reactions.

In plant growing, serodiagnosis is used in the determination of the infestation of plants by various pathogens, in the specific diagnosis of fungi, bacteria, and viruses, and in the tentative evaluation of plant resistance to various diseases. It is based on the administration of diagnostic serums, which are most often prepared from rabbits. The serologic method makes it possible to discern viruses and bacteria in plants exhibiting obvious disease symptoms and in plants with no visible symptoms, which facilitates the diagnosis of latent infestation in plants and the selection of healthy stock and grafts.

The serodiagnosis of viruses, bacteria, and fungi involves the use of immunofluorescence which is based on the administration of diagnostic serums containing antibodies combined (conjugated) with fluorescent substances. In plant cells and tissue the luminescence of antibodies reacting with their corresponding viruses, bacteria, or fungi permits the direct detection and determination of a pathogen, even when the pathogen is combined with other microorganisms.


References in periodicals archive ?
Evaluation of cysticercosisfasciolaris antigen for the immunodiagnosis of neurocysticercosis.
In the present study, we have made an attempt to assess the usefulness of hydrocele fluid (which is usually discarded after surgical operation) for immunodiagnosis of lymphatic filariasis by detecting different filarial antibody isotypes and cytokine profiles.
Regulatory t cells and TH1/TH2 cytokines as immunodiagnosis keys in systemic autoimmune diseases.
Early immunodiagnosis of Fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
Voller, "The immunodiagnosis of malaria," in Malaria Principles and Practice of Malariology, W.
It provides conventional methods such as incubation diagnostics and immunodiagnosis.
This antibody has low affinity which limits its potential use for immunodiagnosis and immunotherapy.
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.
10) Detection of the Og4C3 antigen, by either immunochromatography or ELISA, has proven to be a specific and sensitive method for the immunodiagnosis of Wuchereria bancrofti infections.
This has led to an overestimation of the adjunct role of IHC, such that a diagnosis of MM has become almost entirely an immunodiagnosis rather than a diagnosis first based on the microscopic examination of a good-quality, conventional, hematoxylin-eosin-stained tissue specimen, supplemented by correlation of the microscopic picture with clinical and imaging data.
16) TST remains a useful tool for the diagnosis of active TB in young children and IGRAs offer equivalent, but not superior performance (17) and immunodiagnosis is not a substitute for molecular or microbiological site-of-disease diagnosis.
Immunodiagnosis in cerebrospinal fluid of cerebral toxoplasmosis and HIV-infected patients using Toxoplasma gondii excreted/secreted antigens.