However, identification of the most immunogenic peptides
requires highly accurate and comprehensive exome sequencing and tumor-specific mutation detection, as well as use of downstream approaches that filter and validate the results to identify the most promising immunotherapy candidates.
The nelipepimut immune response can also generate CTLs to other immunogenic peptides
through inter- and intra-antigenic epitope spreading.
Reduced acidity (elevated pH) reduces ability to absorb minerals including those needed for prevention of asthma, prevent uptake of metal toxins, and break down immunogenic peptides
The topics include generating cytotoxic T lymphocytes for the immunotherapy of EBV-associated malignancies, the enhanced migration of human dendritic cells expressing inducible CD40, constructing human antibody gene libraries and selecting antibodies by phage display, using telomerase reverse transcriptase to identify immunogenic peptides
of the self-tumor antigen, liposomes for gene transfer in cancer therapy, and the cellular immunotherapy of cancer.
The patents, titled "METHOD OF AFFINITY CROSS-LINKING BIOLOGICALLY ACTIVE, IMMUNOGENIC PEPTIDES
TO ANTIBODIES," relate to the Company's ability to create, develop and manufacture antibodies based on its DXL(TM) technology platform.
The strategy was focused on the HER-2/neu-expressing DCIS because of the frequent association with recurrent disease and of course the availability of both major histocompatibility complex (MHC) class 2 and class 1 restricted immunogenic peptides
Among the different immunogenic peptides
, one peptide, with a sequence of Cys-YTLRAPRSPKMVQG, appeared to be the most appropriate candidate, as most immunized mice produced antibodies specific for the pro[BNP.
Once the immunogenic peptides
are identified, specific tetramers for those peptides can be developed to monitor immune response to the vaccine.
In addition, genes involved in coding cancer antigens have been identified, along with the immunogenic peptides
associated with these antigens.
T Cell Receptor (TCR) recognition of immunogenic peptides
bound to major histocompatibility complex (MHC) molecules leads to T cell activation and a variety of effector functions.
Additional studies showed that BL-7010 is specific to gliadins, the immunogenic peptides
present in gluten that cause celiac disease, and does not interact with non-related enzymes or vitamins in the digestive tract.
The WT1 vaccine was assembled from a set of immunogenic peptides
that are capable of stimulating both CD4 and CD8 T cells.