For example, the coupling of test substances to proteins and exposure of DCs to the haptenated proteins would facilitate a more specific response to test substances and address more specifically the response to immunogenic peptides
. The disadvantage of this approach is that it increases the complexity of the assays and needs careful characterization of the conjugates (e.g., using mass-spectrometry).
Furthermore, the tumor antigens could be modified to fuse or mix with cytokines, antibodies, or immunogenic peptides
in the protein/peptide-based cancer vaccines, e.g., Oncophage for kidney cancer, melanoma, and brain cancer and Stimuvax (BLP25 liposome vaccine) targeting MUC1 for NSCLC and breast cancer [34, 62, 63].
from HER2/neu protein were firstly designed by using bioinformatics.
Reduced acidity (elevated pH) reduces ability to absorb minerals including those needed for prevention of asthma, prevent uptake of metal toxins, and break down immunogenic peptides
The topics include generating cytotoxic T lymphocytes for the immunotherapy of EBV-associated malignancies, the enhanced migration of human dendritic cells expressing inducible CD40, constructing human antibody gene libraries and selecting antibodies by phage display, using telomerase reverse transcriptase to identify immunogenic peptides
of the self-tumor antigen, liposomes for gene transfer in cancer therapy, and the cellular immunotherapy of cancer.
The patents, titled "METHOD OF AFFINITY CROSS-LINKING BIOLOGICALLY ACTIVE, IMMUNOGENIC PEPTIDES
TO ANTIBODIES," relate to the Company's ability to create, develop and manufacture antibodies based on its DXL(TM) technology platform.
Degenerate binding of immunogenic peptides
to HLA-DR proteins on B cell surfaces.
The strategy was focused on the HER-2/neu-expressing DCIS because of the frequent association with recurrent disease and of course the availability of both major histocompatibility complex (MHC) class 2 and class 1 restricted immunogenic peptides
. Essentially, activated DC1 cells (high interleukin-12-secreting dendritic cells) were prepared from autologous monocytes from 13 patients.
Among the different immunogenic peptides
, one peptide, with a sequence of Cys-YTLRAPRSPKMVQG, appeared to be the most appropriate candidate, as most immunized mice produced antibodies specific for the pro[BNP.sub.1-108] molecule (with no cross-reaction with [BNP.sub.1-32] or NT-pro[BNP.sub.1-76]).
Once the immunogenic peptides
are identified, specific tetramers for those peptides can be developed to monitor immune response to the vaccine.
In addition, genes involved in coding cancer antigens have been identified, along with the immunogenic peptides
associated with these antigens.
T Cell Receptor (TCR) recognition of immunogenic peptides
bound to major histocompatibility complex (MHC) molecules leads to T cell activation and a variety of effector functions.