immunologic tolerance


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immunologic tolerance

[¦im·yə·nə¦läj·ik ′täl·ə·rəns]
(immunology)
A condition in which an animal will accept a homograft without rejection.
A state of specific unresponsiveness to an antigen or antigens in adult life as a consequence of exposure to the antigen in utero or in the neonatal period.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia.
Immune Tolerance Therapy: A New Method for Treatment of Traumatic Brain Injury
In their attempt to augment the immune response, anti-PD-1 agents can breach immunologic tolerance by upregulating autoreactive T cells.
Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab
IL-10 is "a key anti-inflammatory cytokine in immunologic tolerance," according to the authors.
Soil, microbes, and allergies
While recent studies show a clear relationship between some commensals and immunologic tolerance, the antigen-specificity of these Treg responses has not been adequately characterized.
Toll-like receptor 2 as a regulator of oral tolerance in the gastrointestinal tract
mTOR inhibitors induce anergy in naive T cells, promote the expansion of regulatory T cells, and inhibit the maturation of dendritic cells, thus promoting immunologic tolerance. Here we review the mechanisms by which mTOR inhibitors promote tolerance.
The evolving role of mTOR inhibition in transplantation tolerance

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