immunologic tolerance


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Related to immunologic tolerance: oral tolerance

immunologic tolerance

[¦im·yə·nə¦läj·ik ′täl·ə·rəns]
(immunology)
A condition in which an animal will accept a homograft without rejection.
A state of specific unresponsiveness to an antigen or antigens in adult life as a consequence of exposure to the antigen in utero or in the neonatal period.
References in periodicals archive ?
Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia.
In their attempt to augment the immune response, anti-PD-1 agents can breach immunologic tolerance by upregulating autoreactive T cells.
IL-10 is "a key anti-inflammatory cytokine in immunologic tolerance," according to the authors.
While recent studies show a clear relationship between some commensals and immunologic tolerance, the antigen-specificity of these Treg responses has not been adequately characterized.
mTOR inhibitors induce anergy in naive T cells, promote the expansion of regulatory T cells, and inhibit the maturation of dendritic cells, thus promoting immunologic tolerance. Here we review the mechanisms by which mTOR inhibitors promote tolerance.