Of the 40% of the pigs that were antibody negative, 10% were genome positive; possible explanations are that serum samples were taken either from acutely infected animals before induction of a detectable antibody response or from persistently infected animals lacking a specific humoral immune response due to a specifically acquired immunotolerance
, a well-known consequence of intrauterine pestivirus infections.
Hus, "Breaking immunotolerance
of tumors: a new perspective for dendritic cell therapy," Journal of Immunotoxicology, vol.
It took a long time before I understood why: my body had fallen out of immunotolerance
(the understanding that parts of the self, organs, blood proteins, the like, are not to be cripplingly attacked and destroyed by the body's own immune system).
Our study further confirmed that immunotolerance
against Graves' disease could be induced in neonatal mice with higher-dose Ad-TSHR289 by intraperitoneal pathway.
My preliminary studies in human endometrial cells suggest that aryl hydrocarbon receptor (AHR) regulates genes that are essential for placental development and maternal immunotolerance
of the fetus.
Patients receive more intense immunosuppression during the immediate post-transplant period, which promotes a significant increase in viral load associated with a pattern of immunotolerance
Merck Serono has also a pre-clinical pipeline of therapeutic cancer vaccines, cancer stem cells, and tumour immunotolerance
with cellular therapies (mesenchymal stem cells)is possible and appears to be promising.