Myositis

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myositis

[‚mī·ə′sīd·əs]
(medicine)
Inflammation of muscle. Also known as fibromyositis.

Myositis

 

inflammation of skeletal muscles. It usually affects the entire muscular system, that is, it occurs as polymyositis.

Myositis can occur in a variety of diseases and is generally a sign of collagen diseases, that is, systemic diseases of connective tissue. The disease may be acute, subacute, or chronic. Muscle symptoms are often combined with skin disturbances (reddening, edema, induration)—dermatomyositis. A particular form of the disease is parasitic myositis, which results from parasites (Trichinella, Echinococcus, Cysticercus) invading muscles. Another form is myositis ossificans, in which bony tissue forms in muscles. Patients complain of pain in the muscles, muscular weakness, and incoordination; muscular sclerosis and contractures develop in the later stages of the disease. Treatment includes hormone therapy, vitamin therapy, administration of analgesics, and, when indicated, antiparasitic therapy.

REFERENCE

Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)

V. A. KARLOV

References in periodicals archive ?
* The report assesses Inclusion Body Myositis (IBM) therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type
* A review of the Inclusion Body Myositis (IBM) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Inclusion body myositis. Curr Opin Rheumatol 2011;23:574-8.
The most common acquired muscle disease in people over 50 years of age, inclusion body myositis (IBM) is a distinct type of inflammatory myopathy characterized by slowly progressing, degenerative muscle changes caused by an antigen-driven inflammatory response, as well as vacuolar degeneration and abnormal protein deposits in distal and proximal muscle cells, Dr.
Other considerations included dermatomyositis (DM), inclusion body myositis, or possibly a viral myopathy.
Arimoclomol, the company's lead candidate, is in clinical development for the four orphan diseases of Niemann-Pick disease Type C, Gaucher disease, sporadic Inclusion Body Myositis, and Amyotrophic Lateral Sclerosis.
PM is an exclusion diagnosis once other myopathies are ruled out like DM, autoimmune necrotizing myositis, and inclusion body myositis. A muscle biopsy is required to make a definite diagnosis.
[USPRwire, Mon May 04 2015] Global Markets Direct's, 'Inclusion Body Myositis (IBM) - Pipeline Review, H1 2015', provides an overview of the Inclusion Body Myositis (IBM)'s therapeutic pipeline.
Taivassalo noted that patients with sporadic inclusion body myositis improved aerobic capacity and muscle strength as well as combined AT and low-intensity ST of the upper and lower limbs without unfavourable muscle symptoms or further increases in baseline CK.
Idiopathic inflammatory myopathies, comprising dermatomyositis, polymyositis and inclusion body myositis, (1) represent the largest group of acquired and potentially treatable causes of skeletal muscle weakness.