Stadtlanders has not set a price yet for indinavir
, which a study has shown can cut virus levels by 89 percent.
However, Trauger says he believes the Salk vaccine will remain useful long after the AIDS virus develops resistance to Indinavir
and other more conventional anti-AIDS drugs already on the market.
No important drug interaction between tenofovir and indinavir
, lopinavir, 3TC, or efavirenz;
Now survival rates run two years or more, even before the introduction of indinavir
, ritonavir and other protease inhibitors.
Data from the MaxCmin1 trial, presented today at ICAAC, showed that boosted indinavir
led to significantly greater increases in lipid levels at 48 weeks compared to boosted saquinavir.
In ACTG 343, a full 23% of patients randomized to the indinavir
arm and the zidovudine/lamivudine arm had viral rebounds.
One study focused on the amount of HIV in the body, showing that the indinavir
combination reduced the amount of HIV to levels that could not be detected by standard laboratory tests in 26 patients over 24 weeks.
Drugs analyzed in this first phase of method development include indinavir
(Merck), delavirdine (Pharmacia & Upjohn), ritonavir (Abbott Laboratories), nelfinavir (Agouron Pharmaceuticals) and saquinavir (Hoffman LaRoche).
The drug's new labeling states that concomitant use of Cafergot in conjunction with potent Cyp 3A4 inhibitors--such as ritonavir, nelfinavir, indinavir
, erythromycin, and clarithromycin--is contraindicated.
The analysis of 48-week data showed that boosted saquinavir reduced HIV viral load to undetectable levels (less than 400 copies/mL) in 68 percent of patients, while boosted indinavir
reduced HIV viral load to undetectable levels in 53 percent of patients (p=0.
A study of indinavir
(Crixivan) blood levels in patients using marijuana [4% THC cigarettes three times a day for 14 days] in the marijuana clinical trial at the University of California San Francisco found that indinavir
levels may be decreased.
However, combinations of ritonavir with either amprenavir (Agenerase) or indinavir
(Crixivan) should also be very potent.