indirubin


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indirubin

[‚in·də′rü·bən]
(organic chemistry)
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For instance, Linarin (MOL001790, DL=0.71, OB=39.8%), 7,4'-Dihydroxyflavanone (MOL001792, DL=0.18, OB=32.8%), Neohesperidin_qt (MOL001798, DL=0.27, OB=71.2%), Saponaretin (MOL002322, DL=0.72, OB=31.3%) and Indirubin (MOL002309, DL=0.26, OB=48.6%) were reported to exhibit anti-viral activity.
Most authors believe that purple urine is a mixture of indigo and indirubin, which are derived from the metabolites of tryptophan, an essential amino acid in the body.
This increase in "raw materials" provides increased levels of indigo and indirubin responsible for the appearance of PUBS.
Qian, "Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China," Leukemia & Lymphoma, vol.
In the presence of indoxyl phosphatase and sulphatase enzyme activities, whilst collected in the catheter system, UIS is degraded to form a mixture of indigo and dissolved indirubin in the plastic (11), coating the catheter system with a purple appearance.
The pathogenesis of purple urine bag syndrome is due to the metabolism of tryptophan by bacteria to indole and later converted to indicant in the liver.[sup.3] This is excreted and broken down in the urine by bacteria possessing one or both enzymes, sulphatise and phosphatase that metabolize this pigment to indirubin and indigo in an alkaline environment (urine).
Solove Research Institute (OSUCCC - James) - discovered that the compound, indirubin, both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels that the tumor needs to grow.
In the last two years, French molecular biologists have isolated indirubin, a compotent of indigo as being effective in treating certain strains of leukaemia.
Laurent Meijer, of the Roscoff Biological Station in France, found the active ingredient was a red pigment called indirubin which reduces the protein needed when cells multiply.
Indirubin, which is extracted from indigo and an active ingredient of Danggui Longhui Wan, is the first traditional Chinese medicine extract shown to be effective for treatment of chronic myelogenous leukemia [17].
Hopper, "In vitro antifungal activity of indirubin isolated from a South Indian ethnomedicinal plant Wrightia tinctoria R.
PUBS is an uncommon phenomenon in which purple discoloration of catheter bag is due to the presence of blue pigment indigo and red pigment indirubin.[2,4] The proposed mechanism for pigment production is through altered metabolism of tryptophan.