erythropoiesis

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erythropoiesis

[ə‚rith·rə‚pȯi′ē·səs]
(physiology)
The process by which erythrocytes are formed. Also known as erythrocytopoiesis.
References in periodicals archive ?
Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in [beta]-thalassemia.
For example, surplus unpaired a-haemoglobin chains were disintegrated and autoxidised in AY- thalassaemia, resulting in ineffective erythropoiesis, increased oxidant production, haemolysis and reduced RBC survival.
reported that transgenic hepcidin overexpression in [beta]-thalassemia intermedia mice decreased iron overload, and even ameliorated ineffective erythropoiesis (207).
So direct destruction and ineffective erythropoiesis does not adequately explain the cause of anaemia in malaria.
In our study, we used super-transfusion regimen to maintain normal physiological level of haematocrit/haemoglobin in transfusion dependent betathalassemia major patients, which leads to better tissue oxygenation, reduction of blood volume, reduced intestinal absorption of iron by reducing plasma iron turnover [25] and benefit on bone development by reducing in the rate of ineffective erythropoiesis.
12] Tumor necrosis factor-alpha has also been implicated and may cause ineffective erythropoiesis.
The above results are in line with the theory that iron absorption is increased in a variety of refractory anemias characterized by erythroid hyperplasia in conjunction with ineffective erythropoiesis.
Indeed, our studies show that ALN-TMP administration results in reduced iron overload, decreased extra-medullary hematopoiesis, increased hemoglobin levels, and a reduction in ineffective erythropoiesis.
1] Further, thalassemia is a serious disease causing severe anemia, ineffective erythropoiesis, extramedullary hematopoiesis, and iron overload resulting from transfusion and increased iron absorption.
These problems are caused by multiple factors but mainly because of erythroid expansion due to ineffective erythropoiesis, and resultant cortical thinning.
Transferrin receptor concentrations are increased in disorders with expanded erythropoiesis, such as hemolytic anemias [15, 16, 18], and in conditions associated with ineffective erythropoiesis, such as myelodysplastic syndromes and megaloblastic anemias [21, 22].
This will reduce the imbalance of alpha-beta/no alpha globin chain ratio in red cells and ameliorate the biochemical defects in hemoglobin molecule and partially correct the ineffective erythropoiesis.

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