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Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction.



a focus of organ or tissue necrosis resulting from an interruption of the blood supply to the area. The direct causes of infarcts are thrombosis, embolism, or spasm of the arteries feeding this tissue. Hypoxia is a decisive factor in the development of the tissue changes associated with an infarct.

There are three types: white, or ischemic, infarct, which is a zone of necrosis lacking in blood; red, or hemorrhagic, infarct, in which the zone of necrosis is saturated with excessive blood; and ischemic infarct with a hemorrhagic zone. The first and third types of infarct are generally formed in the heart, kidneys, and spleen, and the second in the lungs and intestine. An infarct may be conical (kidney, lungs) or irregular (heart, brain) in shape. Its consistency varies with the nature of the necrosis, which may be dry (myocardial infarct) or moist (cerebral infarct).

Infarcts cause profound changes in the organs affected. The dead areas are resorbed or organized, resulting in the formation of a cyst (in the brain) or a scar (in the heart muscle), or they may suppurate and liquefy (septic infarct). The size, location, and properties of an infarct determine whether the affected organ becomes weakened or loses its functions.


References in periodicals archive ?
1 Occlusion of this artery results in a distinctive pattern of bilateral thalamic infarcts with or without midbrain infarction.
KEYWORDS: Acute weakness, Cerebral infarct, Monoparesis.
Patients who had both ILLs and large infarcts were nine times more likely to have a stroke and seven times more likely to die from a stroke than were patients who had no lesions.
In our study, DW ASPECTS score was used as an important method to assess the radiological severity of MCA infarct.
A third of stroke survivors will be diagnosed with depression according to various depression rating scales any time after their infarct (Hackett et al.
Also, the offending vein is not always identified when small cortical veins are involved, presumably from recanalization after the subsequent insult by hemorrhage or infarct occurs.
5 Tesla indicated periventricular hyperintensity (PVH) which showed a grade-3 PVH pattern using Fazekas' method [5,6], although MRI did not indicate lacunar infarct because the patient underwent MRI studies directly after the infarct had developed.
Infarcts were noted on gross examination and extent of placental infarct was recorded in terms of percentage of infarcted area (nil/less than 5%, 5-25%, 25-50%, greater than 50%) and their pattern of distribution (focal/multifocal/diffuse).
The patients with infarct had an average level of 350 mg/dl and the patients of intracranial bleed had an average level of 324 mg/dl.
In our study, the highest serum S100B levels, especially on the third day, correlated well with the infarct volume, and this result led us to think that serum S100B levels show the width of brain injury and can be used as a peripheral marker.
Capricor is now enrolling ALLSTAR Phase 2, a clinical trial evaluating the effectiveness of CAP-1002 in reducing infarct size in patients who have suffered a myocardial infarction (heart attack) more than 30 days and less than 12 months prior to treatment with CAP-1002.
The reduction in infarct size was accompanied by a similarly significant reduction in LV mass through one year.