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Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a focus of organ or tissue necrosis resulting from an interruption of the blood supply to the area. The direct causes of infarcts are thrombosis, embolism, or spasm of the arteries feeding this tissue. Hypoxia is a decisive factor in the development of the tissue changes associated with an infarct.

There are three types: white, or ischemic, infarct, which is a zone of necrosis lacking in blood; red, or hemorrhagic, infarct, in which the zone of necrosis is saturated with excessive blood; and ischemic infarct with a hemorrhagic zone. The first and third types of infarct are generally formed in the heart, kidneys, and spleen, and the second in the lungs and intestine. An infarct may be conical (kidney, lungs) or irregular (heart, brain) in shape. Its consistency varies with the nature of the necrosis, which may be dry (myocardial infarct) or moist (cerebral infarct).

Infarcts cause profound changes in the organs affected. The dead areas are resorbed or organized, resulting in the formation of a cyst (in the brain) or a scar (in the heart muscle), or they may suppurate and liquefy (septic infarct). The size, location, and properties of an infarct determine whether the affected organ becomes weakened or loses its functions.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Our method for the calculation of the infarcted prostatic volume was not accurate (particularly for irregularly shaped infarcts) and we did not utilize transrectal US (TRUS)/TRCEUS, which could have provided a more detailed depiction of the infarcts (12).
Pretreatment of infarcted group with either RFAE or GFAE induced significant reduction in the levels of ALT, AST, LDH, CK-MB , cTnI, TNF-[alpha] , IL-6 , TC, TG, LDL-C and vLDL-C relative to non-treated ISO-group (Tables II, III, IV).
For example, a study by Vandergriff and coworkers demonstrated that magnetic targeting can increase cell retention and engraftment of cardiosphere-derived SCs to the infarcted rat myocardium ~4-fold compared to control where no magnet was applied [71].
On comparison of the effect of different contrast agents on [T.sub.1] relaxivity, the difference in mean [T.sub.1] between infarcted and remote myocardium was highly significant across all contrast agents as well as native [T.sub.1] mapping.
Characterization of infarcted myocardial tissue--Area at risk
Microscopic findings useful in differential diagnosis of uterine mesenchymal tumors (adapted after [1]) Histological STUMP/ criteria LMS Infarcted LM STUMP Nuclear Moderate-severe None-mild Moderate- atypia None-mild severe Moderate-severe Tumor +/- + - necrosis Mitotic Any 5-9/ count [greater than <10 atypical (per 10HPF) or equal to] 10 mitoses Histological Atypical Mitotically criteria LM active LM LM Nuclear Focal None-mild None- atypia moderate- mild severe Tumor - - - necrosis Mitotic count <5 [greater than <5 (per 10HPF) or equal to] 5
A significant reduction in BP variability was observed in the infarcted animals throughout the entire post-infarction period without a tendency toward recovery.
[V.sub.infarcted hemisphere tissue] is the volume of the infarcted hemisphere tissue.
Successful induction of MI was verified by color change immediately in the infarcted area.
PiCSO therapy is provided during the stenting procedure and intermittently increases pressure in the coronary venous system which leads to an improved microcirculatory flow and improved perfusion of the infarcted area, ultimately leading to a smaller residual infarct size after AMI compared to non PiCSO treated patients.
Of the 15 cases, infarcted spleen in 6 patients (40%), pseudocyst in 4 patients (26.7%), abscess in 2 patients (13.2%), epithelial cyst in 1 patient (6.7%) and lymphangioma in 1 patient (6.7%) and littoral cell angioma in 1 patient (6.7%) were diagnosed.
Re-establishing cerebral perfusion is only of benefit if brain tissue is not completely infarcted. Identifying patients who have ischaemic but still viable tissue, the penumbra, is important, as is not selecting patients with large established infarcts.