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Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction.



a focus of organ or tissue necrosis resulting from an interruption of the blood supply to the area. The direct causes of infarcts are thrombosis, embolism, or spasm of the arteries feeding this tissue. Hypoxia is a decisive factor in the development of the tissue changes associated with an infarct.

There are three types: white, or ischemic, infarct, which is a zone of necrosis lacking in blood; red, or hemorrhagic, infarct, in which the zone of necrosis is saturated with excessive blood; and ischemic infarct with a hemorrhagic zone. The first and third types of infarct are generally formed in the heart, kidneys, and spleen, and the second in the lungs and intestine. An infarct may be conical (kidney, lungs) or irregular (heart, brain) in shape. Its consistency varies with the nature of the necrosis, which may be dry (myocardial infarct) or moist (cerebral infarct).

Infarcts cause profound changes in the organs affected. The dead areas are resorbed or organized, resulting in the formation of a cyst (in the brain) or a scar (in the heart muscle), or they may suppurate and liquefy (septic infarct). The size, location, and properties of an infarct determine whether the affected organ becomes weakened or loses its functions.


References in periodicals archive ?
Fibrosis and stenosis of the long penetrating cerebral arteries: The cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
(i) Multiple acute infarcts: MRI: multiple noncontiguous lesions, which were hyperintense on DWI and hypointense on ADC maps; CT: multiple, noncontiguous, and hypodense lesions
However, here we report a rare case of thrombosis which involves both venous and arterial thrombosis of 2 different organ systems, namely, the lung as pulmonary embolism and the spleen as splenic infarct, respectively.
After reviewing the images with a neuroradiologist, it was determined that the new acute infarcts found in the occipital lobes, superior cerebellum, and thalamus were within the PTA territory.
Lateralization as a factor in the prognosis of middle cerebral artery territorial infarct. Eur Neurol, 2002; 48: 141-5.
The effect of long-term hypertension impairs microvascular function, inhibiting blood flow and slowing return perfusion to an area of infarct (Oh et al., 2012).
We encountered the rare case of an elderly patient who showed marked deterioration of the cognitive function and prolonged cognitive impairment after her first lacunar infarct at the right internal capsule.
The study found that an increase of only 2[acute accent]g per cubic meter in PM2.5, a range commonly observed across metropolitan regions in New England and New York, was associated with being more likely to have covert brain infarcts and smaller cerebral brain volume, equivalent to approximately one year of brain aging.
Imaging and laboratory examinations play an essential role in diagnosis of CADASIL: the key diagnostic features include (1) Leukoaraiosis and multiple small infarcts presented bilaterally in deep white matter, basal ganglia, thalamus, and pons on MRI; (2) granular and osmiophilic substance layers around the vascular smooth muscles in the brain, skeletal muscle, peripheral nerves, and skin verified by electron microscopy; and (3) NOTCH3 mutations confirmed by DNA analysis [22].
SuperSaturated Oxygen Therapy was designed to increase the amount of oxygen in the blood serving the heart muscle affected by the heart attack (infarct) to help prevent the tissue from dying.