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Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction.



a focus of organ or tissue necrosis resulting from an interruption of the blood supply to the area. The direct causes of infarcts are thrombosis, embolism, or spasm of the arteries feeding this tissue. Hypoxia is a decisive factor in the development of the tissue changes associated with an infarct.

There are three types: white, or ischemic, infarct, which is a zone of necrosis lacking in blood; red, or hemorrhagic, infarct, in which the zone of necrosis is saturated with excessive blood; and ischemic infarct with a hemorrhagic zone. The first and third types of infarct are generally formed in the heart, kidneys, and spleen, and the second in the lungs and intestine. An infarct may be conical (kidney, lungs) or irregular (heart, brain) in shape. Its consistency varies with the nature of the necrosis, which may be dry (myocardial infarct) or moist (cerebral infarct).

Infarcts cause profound changes in the organs affected. The dead areas are resorbed or organized, resulting in the formation of a cyst (in the brain) or a scar (in the heart muscle), or they may suppurate and liquefy (septic infarct). The size, location, and properties of an infarct determine whether the affected organ becomes weakened or loses its functions.


References in periodicals archive ?
As such in a young patient like ours with no previous co-morbids presenting with only generalized CNS signs and symptoms; cerebrovascular infarcts would be low on a list of differential diagnosis.
Diffusion-weighted magnetic resonance imaging (DWI-MR) revealed a focal high intensity signal in the right precentral gyrus at high convexity with a cerebral infarct.
Patients who had both ILLs and large infarcts were nine times more likely to have a stroke and seven times more likely to die from a stroke than were patients who had no lesions.
The imaging protocols include mainly axial T2 FLAIR, DWI and MRA Statistical Severity of MCA infarct assessed as Analysis percentage and frequency.
Infarcts of the lower pontine region of the brain are strongly associated with PMD.
Understanding the pathophysiology of venous thromboses and infarcts helps to explain the imaging manifestations and natural evolution of venous infarcts.
It is known that lacunar infarcts cause mild symptoms, but this case adds new findings regarding such infarcts.
Conclusion: The present study showed decrease in placental weight, increase in placental infarcts and syncytial knot hyperplasia at low maternal hemoglobin concentration, displaying adaptive alterations.
These small vessels changes lead to small infarcts in the white matter, deep gray matter and the pons.
showed that S100B values of 26 acute stroke patients, assessed on the 1st, 3rd, and 7th days, reached maximum levels in patients with infarcts larger than 2/3 of the middle cerebral artery territory on the 3rd day, and they indicated these findings as poor outcome and disability (25).
Research shows that silent brain infarcts, which are only detected by brain scans, are found in about 20 percent of otherwise healthy elderly people.