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A discrete nodular lesion of inflammatory tissue in which granulation is significant.



a focal growth of inflammatory origin in the cells of young connective tissue in the form of a small node.

Granuloma develops in connection with various (most often infectious) processes (tuberculosis, syphilis, leprosy, brucellosis, tularemia, actinomycosis), with collagenic diseases (such as rheumatism), and at the sites of entry of foreign bodies. Certain granulomas have more specific names, such as the tubercle in tuberculosis and the gumma in syphilis.

References in periodicals archive ?
This type of nonnecrotizing vasculitis is common in infectious granulomas (10) (Figure 7, F).
Histologic clues that favor infectious granulomas include admixed compact, sarcoidlike, nonnecrotizing granulomas (148) and lymph node involvement, both of which are absent in Wegener granulomatosis.
The changes described above are histologically indistinguishable from infectious necrotizing granulomas, which, of course, may occur in patients with rheumatoid arthritis; infectious granulomas can also be multiple, bilateral, and subpleural.

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