Of interest, the data suggest a form of sensitization; that sound exposure alters how neurons in inferior colliculus
respond to a subsequent somewhat prolonged (90 min) presentation of a pure-tone sound stimulus.
The results indicate the possibility of the involvement of superior olivary complex and inferior colliculus
in the auditory pathways as the levels of affection.
Each animal was anaesthetized through the administration of a mixture of tiletamine/zolazepam (1: 1; Zoletil 100[R]; 50 mg/kg i.p.; VIRBAC Srl, Milan, Italy) and subsequently inserted into a stereotaxic apparatus in order to carry out an accurate craniotomy which, through small holes in the skull, allowed the surgical implantation of two intracranial electrodes in the dura mater, immediately over the cortex, for the electrocorticographic recordings and one electrode in the inferior colliculus
This insignificant alteration in V ipsilateral amplitude may be explained by the fact that the V wave corresponds to the analysis of information at the level of inferior colliculus
. The processing of auditory information is bilateral but is predominantly contralateral starting from the II wave onward.
Schofield, "Projections to the inferior colliculus
from layer VI cells of auditory cortex," Neuroscience, vol.
Diencephalic projections of the inferior colliculus
(nucleus mesencephali lateralis, pars dorsalis).
Manohar et al., "Hyperexcitability of inferior colliculus
and acoustic startle reflex with age-related hearing loss," Hearing Research, vol.
The trochlear nuclei adjoin each other at the midline of the lower midbrain at the level of the inferior colliculus
(Figure 4), just inferior to the central caudal nucleus of the oculomotor complex.
Proper function of the brain requires the inhibition mediated by GABA interneurons, and the lowered inhibition is considered to be involved in the hyperactivity of AC and inferior colliculus
* Wave V--from lateral lemniscus / inferior colliculus
Auditory Brainstem Response (ABR) represent volume conducted electrical activity from auditory nerve to inferior colliculus
Interventions such as sensory deprivation, monotonous stimulation, or excessive sound exposure result in impairments of neuronal responsiveness both in the auditory cortex (AC) and in subcortical structures such as the inferior colliculus
(IC) [5, 7-10].