Compared with the NC group, rats in the HF group showed higher levels of body weight, fasting plasma glucose, fasting serum insulin, LDL-c, and a lower level of glucose infusion rate
In this case insulin infusion rates
were tailored for each of the three groups of Zucker rats to produce plateau insulin levels corresponding to those observed in the freely fed postprandial state (2 h after onset of the dark phase) as determined in separate experiments: Lean 30, Obese 120, and Tesaglitazar 60 pmol/[kg.sub.lbm]/min.
Although two nurses were present when Maisie's feed bag was changed, only Mr Woods checked the infusion rate
after telling the other nurse, Lisa Varlass, that she could return to another patient.
It is also possible that there could be some washout of the DADLE into the general circulation in spite of the extremely low coronary infusion rate
. However, none of the typical systemic hemodynamic effects of DADLE (bradycardia, hypotension) were noted and the quantity infused was well below that required to maintain physiologically effective blood levels (16).
Subsequent and serial adjustments in fluid infusion rate
are then based upon response to resuscitation.
Blood glucose (mmol/l) Insulin infusion rate
(ml/h) 0-4 0.5 (call doctor) 4.1-7.0 1 7.1-11.0 2 11.1-15.0 3 15.1-20.0 4 >20 6 (call doctor)
Higher infusion rates
may, however, lead to complete loss of responsivity.
Closed infusion containers ensure a consistent, even infusion rate
throughout the administration process without the assistance of a mechanical device (e.g., infusion pump).
The glucose infusion, also delivered by a Harvard Infusion pump, was begun at the 4th minute and the infusion rate
was empirically set at 2.0 mg/kg/min (SI: 0.01 mM/kg/min) up to 10th minute.
Euglycemic clamps were used to measure insulin sensitivity and clearance, keeping the insulin infusion rate
steady for all subjects and obtaining a direct measure of insulin clearance via steady state plasma insulin (SSPI) levels achieved during the clamp study.
Iron polymaltose (Ferrosig[R] Sigma Pharmaceuticals) 500 mg administered in 500 ml of 0.9% saline using the following infusion rate
Brooks Gentry et al., Effect of Infusion Rate
on Thiopental Dose-Response Relationships, 81 ANESTHESIOLOGY 316 (1994).