IAP

(redirected from inhibitor of apoptosis protein)
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IAP

IAP

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Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.
The cytoplasmic expression of X-linked inhibitor of apoptosis protein was not significantly different in celiac disease (E) and in controls (F).
Mitochondrial proteins that cause caspase-dependent cell death include cytochrome C (Cyt C), which triggers caspase-9 activation by binding and activating the apoptotic protease activating factor-1 (Apaf-1), and Smac/Diablo, which potentiates caspase activation by binding inhibitor of apoptosis proteins (IAP) and blocking their caspase-inhibitory activity.
Livin, a novel inhibitor of apoptosis protein family member.
The inhibitor of apoptosis protein family and its antagonists in acute leukemias.
The study demonstrated that the X-linked inhibitor of apoptosis protein (XIAP) is one of the critical factors in conferring chemotherapy resistance in human prostate cancer cells.
Table 1 List of various pro-apoptotic and anti-apoptotic factors involved in the sepsis Pro-apoptotic factors Anti-apoptotic factors BAX Bcl-2 Bcl-xs Bcl-xl, Bcl-Al BIM, PUMA, NOXA Inhibitor of apoptosis proteins FAS ligand Mcl-1 Tumour necrosis factor- a Ras factor- a BID, BAK Apoptosis-inducing factor p53 BAX=Bcl-2-associated X protein, Bcl=B cell lymphoma, BIM=Bcl-2-interacting moderator of cell death, PUMA=p53- upregulated modulator of apoptosis, NOXA=phorbol-12 myristate-l-acetate-induced protein, FAS=cell surface Fas receptor also known as CD95L, Mcl=M cell lymphoma, Ras=rat sarcoma, BID=BH3 interacting death domain, BAK=Bcl-2 homologous antagonist killer.
ARTS interferes with molecules called inhibitor of apoptosis proteins (IAPs), which prevent cells from killing themselves.

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