The observed initial shrinkage
of the tumour mass is usually the evidence of the killing of the most susceptible cancer cells, which have normal mitochondrial function, leaving cancer stem cells to become resistant.
In spite of its initial shrinkage
, it can be a bear to get out if the alloy has penetrated a rough surface.
We observed drug related anti-tumoractivity in all of the patients, with initial stabilization of the patient's overall disease in five of the first six patients and initial shrinkage
of the primary tumor in three of the six patients.