initiation codon


Also found in: Dictionary, Thesaurus, Medical, Legal.

initiation codon

[i‚nish·ē′ā·shən ′kō‚dän]
(genetics)
A codon that signals the first amino acid in a protein sequence; usually AUG, but sometimes GUG. Also known as start codon.
References in periodicals archive ?
The size of introns in chicken [DELTA]-6 desaturase and the 5'splice donor and 3'splice acceptor (The exon includes initiation codon ATG and termination codon TGA except 3'UTR and 5'UTR) Size 3' splice 5'splice Intron Exon (bp) acceptor donor size (bp) 1 207 CCACG/gtaag 3,374 2 111 tccag/GATGC AAAAT/gtgag 782 3 198 tgcag/TCCCA CCCAG/gtaag 644 4 102 ttcag/GCCCA TTAAG/gtaaa 229 5 126 cccag/GGTGC TTGAG/gtaag 2,003 6 61 cacag/TACGG CCTCA/gtgag 492 7 77 tgcag/TCTTC GGGCG/gtgag 212 8 98 cctag/GACCT GTCAG/gtagg 2,634 9 97 tgaag/GTTTC CTCAG/gtaat 1,137 10 80 tacag/CTGGC CACCA/gtgag 1,103 11 126 tcaag/CCTGT GTTGG/gtaag 526 12 52 cccag/GTCAC
As expected, most eubacteria have a distinct indication of a Shine-Dalgamo region located just upstream from the initiation codon.
Among his many achievements are the Discovery of the Initiation Codon for protein synthesis and hence the start of protein coding (1965 and 1966) the first crystallization of tRNA (1968) and Project leader for X-ray crystallographic structural determination of translation factors and complexes, 1974 through 1994.