initiation complex


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initiation complex

[i‚nish·ē′ā·shən ‚käm‚pleks]
(cell and molecular biology)
An intermediate of protein synthesis consisting of messenger ribonucleic acid, initiator codons, initiation factors, and initiator transfer ribonucleic acid.
References in periodicals archive ?
The now competent 80S initiation complex then proceeds to translation elongation (Figure 1).
RPS23 appears to be involved in the translation initiation step of protein synthesis (McMahon & Landau 1982), constitutes the ribosomal binding site for mRNA in the 40S initiation complex (Takahashi et al.
Eukaryotic translation initiation factor 4B (eIF4B) is also phosphorylated by S6K1 and this phosphorylation promotes the recruitment of eIF4B to eukaryotic initiation factor 4A (eIF4A) at the translation initiation complex where it functions as a cofactor of eIF4A and increases its processivity [74].
Literature suggests that streptomycin irreversibly binds to the 30S ribosome and freezes the 30S initiation complex (30S-mRNA-tRNA), so that no further initiation can occur (Gale et al., 1981).