initiation factor


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initiation factor

[i‚nish·ē′ā·shən ‚fak·tər]
(cell and molecular biology)
Any protein required for the initiation of protein synthesis.
References in periodicals archive ?
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3.
The report provides a snapshot of the global therapeutic landscape for Eukaryotic Translation Initiation Factor 4E (eIF-4E)
Fold Gene Description change elF2 signaling E1F1AX Eukaryotic translation initiation factor 1A, -1.
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Evolutionary relationship between translation initiation factor elF2gamma and selenocysteine-specific elongation factor SELB: change of function in translation factors.
Phosphorylation of initiation factor 2[Alpha] by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.
After the initiation of the ER stress response, it can mediate cellular apoptosis by phosphorylating the eukaryotic translation initiation factor 2a (eIF2a).
The research centred on eukaryotic initiation factor 2 alpha (eIF2alpha) and two enzymes that modify it with a phosphate group; this type of modification is termed phosphorylation.
2011) reported that curcumin inhibited elF3i expression in MCF-7 cells, and our study found that curcumin could inhibit other factors expression, such as IF4A3 (Eukaryotic initiation factor 4A) and IF2A (Eukaryotic initiation factor 2A).
We have identified a small molecule, guanabenz, which binds to a regulatory subunit of protein phosphatase 1, PPP1R15A/GADD34, selectively disrupting the stress-induced dephosphorylation of the alpha subunit of translation initiation factor 2 (eIF2 alpha).
One specific mechanism that may be particularly relevant to the blood-forming cells is the control of the initiation factor eIF2 by phosphorylation, which is stimulated by nitric oxide, thus leading to decreased protein synthesis, presumably including the porphyrin biosynthetic enzymes (Urea et al.