initiation factor


Also found in: Medical, Acronyms, Wikipedia.

initiation factor

[i‚nish·ē′ā·shən ‚fak·tər]
(cell and molecular biology)
Any protein required for the initiation of protein synthesis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Vanishing white matter disease (VWM) is autosomal recessive leukodystrophy linked to mutations in translation initiation factor 2B (eIF2B), and it is the only brain disease recognized to date, which involves this initiation factor.
Rogers, "Role of translation initiation factor 4G in lifespan regulation and age-related health," Ageing Research Reviews, vol.
Kimball, "Eukaryotic initiation factor eIF2," The International Journal of Biochemistry & Cell Biology, vol.
Sullivan et al., "Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK," Journal of Neurochemistry, vol.
* The report provides a snapshot of the global therapeutic landscape for Eukaryotic Translation Initiation Factor 4E (eIF-4E)
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (elF4E) axis.
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Briefly, the eIF4F complex facilitates the association of mRNA with ribosome by interacting with mRNA 5' cap via eIF4E, unwinds the mRNA secondary structures via eIF4A, and recruits the ribosome through eIF4G-eIF3 interaction, thus acting as a cap dependent translation initiation factor [81].
UC Davis assistant Professor Christopher Fraser said that this protein is one the most important initiation factors in this cellular pathway, and there is a lot of energy in the cell that goes into regulating the level and availability of it.
In addition, 4E-BP1, an inhibitory binding partner to the eukaryotic initiation factor 4E, has been linked to muscle size regulation as its inactivation has been widely observed in both in vitro and in vivo models of cell growth (1,2,26) and has been linked to the promotion of skeletal muscle protein synthesis (2).
Gingras et al., "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2," Genomics, vol.