integrase


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integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
References in periodicals archive ?
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor (INSTI) bictegravir, with the demonstrated safety and efficacy profile of the Descovy (FTC/TAF) dual nucleoside reverse transcriptase inhibitor (NRTI) backbone, and is the smallest INSTI-based triple-therapy STR available.
ViiV Healthcare will seek to prove that Gilead Sciences' triple combination HIV drug containing the HIV integrase inhibitor bictegravir infringes ViiV Healthcare's patent covering ViiV Healthcare's dolutegravir and many other compounds that include dolutegravir's unique chemical scaffold.
According to the company, JULUCA is a once-daily, antiretroviral combination of dolutegravir, an integrase strand transfer inhibitor (INSTI) marketed as TIVICAY, and rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed as EDURANT for human immunodeficiency virus type 1 (HIV-1) infection.
The preferred regimens for starting treatment in the major international treatment guidelines have gradually moved towards an NRTI backbone of tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), tenofovir alafenamide/FTC (TAF/FTC) or abacavir/lamivudine (ABC/3TC) plus either the protease inhibitor (PI) darunavir (DRV) boosted by either ritonavir (r) or cobicistat (c), or the integrase inhibitors raltegravir (RAL), elvitegravir (ELV) or dolutegravir (DTG) or the non-nucleoside reverse transcriptase inhibitors rilpivirine (RPV) or efavirenz (EFV)--see EACS Guidelines.
Integrase strand inhibitors (INSTI) are the newest class of antiretroviral (ARV) therapies to treat human immunodeficiency virus (HIV) infection.
Three pair primers were used to obtain the converse regions sequence of the three classes integrase genes respectively while the variable region of the integrons were determined with another pair primers.
The once-daily drug, which belongs to a novel class known as integrase inhibitors that block the virus causing AIDS from entering cells, is owned by ViiV Healthcare, a joint venture that is focused on HIV and in which GSK is the largest shareholder.
29 October 2012 a[euro]" Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.
The product combines the novel HIV integrase inhibitor elvitegravir with a novel "boosting" agent, cobicistat, and Gilead's dual nucleoside/nucleotide reverse transcriptase inhibitor regimen Truvada (emtricitabine/tenofovir).
The topics include advances in the diagnosis of respiratory tract infections, best practice example of pharmaceutical industry's engagement in the fight against malaria, the first oxazolidinone antibacterial agent, the discovery and development of rivaroxaban, and the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium.
Researchers in this study ("Inhibition of feline leukemia virus replication by the integrase inhibitor raltegravir," Veterinary Microbiology, 2011) investigated the usefulness of an anti-retroviral drug called raltegrevir that was originally developed for treatment of HIV in humans.
2+] ions on the interaction between 3,5-dicaffeoylquinic acid and HTLV-I integrase