integrase

[′int·ə‚grās]

(biochemistry)

An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.

References in periodicals archive ?

Biktarvy combines the novel, unboosted integrase strand transfer inhibitor (INSTI) bictegravir, with the demonstrated safety and efficacy profile of the Descovy (FTC/TAF) dual nucleoside reverse transcriptase inhibitor (NRTI) backbone, and is the smallest INSTI-based triple-therapy STR available.

United States : U.S. Food and Drug Administration Approves Gileads Biktarvy (Bictegravir, Emtricitabine, Tenofovir Alafenamide) for Treatment of HIV-1 Infection

ViiV Healthcare will seek to prove that Gilead Sciences' triple combination HIV drug containing the HIV integrase inhibitor bictegravir infringes ViiV Healthcare's patent covering ViiV Healthcare's dolutegravir and many other compounds that include dolutegravir's unique chemical scaffold.

GlaxoSmithKline, Pfizer venture files patent infringement litigation against Gilead

According to the company, JULUCA is a once-daily, antiretroviral combination of dolutegravir, an integrase strand transfer inhibitor (INSTI) marketed as TIVICAY, and rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed as EDURANT for human immunodeficiency virus type 1 (HIV-1) infection.

Janssen Therapeutics passes US FDA approval for the first, complete, single-pill, two-drug regimen JULUCA for HIV-1 infection

The preferred regimens for starting treatment in the major international treatment guidelines have gradually moved towards an NRTI backbone of tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), tenofovir alafenamide/FTC (TAF/FTC) or abacavir/lamivudine (ABC/3TC) plus either the protease inhibitor (PI) darunavir (DRV) boosted by either ritonavir (r) or cobicistat (c), or the integrase inhibitors raltegravir (RAL), elvitegravir (ELV) or dolutegravir (DTG) or the non-nucleoside reverse transcriptase inhibitors rilpivirine (RPV) or efavirenz (EFV)--see EACS Guidelines.

2-Drug regimens in HIV treatment: pharmacological considerations

Integrase strand inhibitors (INSTI) are the newest class of antiretroviral (ARV) therapies to treat human immunodeficiency virus (HIV) infection.

Prevalence of integrase strand inhibitor resistance in New Orleans, Louisiana, 2012-2013

Three pair primers were used to obtain the converse regions sequence of the three classes integrase genes respectively while the variable region of the integrons were determined with another pair primers.

CagA status and genetic characterization of metronidazole resistant strains of H. pylori from a region at high risk of gastric cancer

The once-daily drug, which belongs to a novel class known as integrase inhibitors that block the virus causing AIDS from entering cells, is owned by ViiV Healthcare, a joint venture that is focused on HIV and in which GSK is the largest shareholder.

GSK HIV drug gains priority designation

29 October 2012 a[euro]" Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.

Shionogi to get 10% in ViiV Healthcare

The product combines the novel HIV integrase inhibitor elvitegravir with a novel "boosting" agent, cobicistat, and Gilead's dual nucleoside/nucleotide reverse transcriptase inhibitor regimen Truvada (emtricitabine/tenofovir).

HIV treatment-naive option okayed

The topics include advances in the diagnosis of respiratory tract infections, best practice example of pharmaceutical industry's engagement in the fight against malaria, the first oxazolidinone antibacterial agent, the discovery and development of rivaroxaban, and the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium.

Pharmaceutical science to improve the human condition; Prix Galien 2010; winners and finalist candidates of the Prix Galien USA, International, and Pro Bono Humanitarian Awards 2010

Researchers in this study ("Inhibition of feline leukemia virus replication by the integrase inhibitor raltegravir," Veterinary Microbiology, 2011) investigated the usefulness of an anti-retroviral drug called raltegrevir that was originally developed for treatment of HIV in humans.

New treatment for FeLV virus?

2+] ions on the interaction between 3,5-dicaffeoylquinic acid and HTLV-I integrase

Influencia de los iones [Mg.sup.+2] sobre la interaccion entre el acido 3,5-dicafeoilquinico y la integrasa del HTLV-I