integrase


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integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
References in periodicals archive ?
Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) and the most recent antiretroviral approved for treatment of HIV-1 infection.
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor (INSTI) bictegravir with the demonstrated safety and efficacy profile of the Descovy[R] (emtricitabine 200mg/tenofovir alafenamide 25mg; FTC/TAF) dual nucleoside reverse transcriptase inhibitor (NRTI) backbone and is the smallest INSTI-based triple-therapy STR available.
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor, or INSTI, bictegravir with the demonstrated safety and efficacy profile of the Descovy dual nucleoside reverse transcriptase inhibitor, or NRTI, backbone and is the smallest INSTI-based triple-therapy STR available.
The product is a new once-daily, single-pill and two-drug regimen approved for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing around 40kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine.
SEATTLE -- A long-acting, injectable combination of the novel integrase inhibitor cabotegravir (CAB) and the second-generation nonnucleoside reverse transcriptase inhibitor rilpivirine (RPV) was noninferior to dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) in one phase 3 study (FLAIR) and to three-drug oral antiretroviral therapy (ART) more broadly in the companion ATLAS phase 3 study.
The same analysis linked 2 factors to higher bone mineral density: higher body mass index (a measure of weight) and longer treatment with HIV drugs in the integrase inhibitor class: raltegravir (also called Isentress), dolutegravir (also called Tivicay), and elvitegravir (one of the components of Stribild and Genvoya).
The correlations between viral suppression or continuous viral load (VL) levels with demographic factors, substance use, adherence, and integrase strand transfer inhibitor (ISTI) use were examined.
It includes a fragment (named R4') inserted into the umuC gene, which is characterized by a phage integrase (ORF38) and a phage integrase family site-specific recombinase (ORF37) and encodes 9 genes from different origins with various functions.
The preferred regimens for starting treatment in the major international treatment guidelines have gradually moved towards an NRTI backbone of tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), tenofovir alafenamide/FTC (TAF/FTC) or abacavir/lamivudine (ABC/3TC) plus either the protease inhibitor (PI) darunavir (DRV) boosted by either ritonavir (r) or cobicistat (c), or the integrase inhibitors raltegravir (RAL), elvitegravir (ELV) or dolutegravir (DTG) or the non-nucleoside reverse transcriptase inhibitors rilpivirine (RPV) or efavirenz (EFV)--see EACS Guidelines.
(2) These include the NRTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), PIs, a fusion inhibitor (FI), a CCR5 antagonist, and, more recently, integrase strand transfer inhibitors (INSTIs).