integrase


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integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) and the most recent antiretroviral approved for treatment of HIV-1 infection.
MoHSS introduces new effective HIV drug
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor (INSTI) bictegravir with the demonstrated safety and efficacy profile of the Descovy[R] (emtricitabine 200mg/tenofovir alafenamide 25mg; FTC/TAF) dual nucleoside reverse transcriptase inhibitor (NRTI) backbone and is the smallest INSTI-based triple-therapy STR available.
Gilead Sciences (NASDAQ: GILD) - China National Medical Products Administration Approves Biktarvy[R] (Bictegravir, Emtricitabine and Tenofovir Alafenamide) for Treatment of HIV-1 Infection -- 9/8/2019
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor, or INSTI, bictegravir with the demonstrated safety and efficacy profile of the Descovy dual nucleoside reverse transcriptase inhibitor, or NRTI, backbone and is the smallest INSTI-based triple-therapy STR available.
Gilead announces China NMPA approval for Biktarvy
The product is a new once-daily, single-pill and two-drug regimen approved for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing around 40kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine.
European Commission grants marketing authorisation to ViiV Healthcare's Dovato
SEATTLE -- A long-acting, injectable combination of the novel integrase inhibitor cabotegravir (CAB) and the second-generation nonnucleoside reverse transcriptase inhibitor rilpivirine (RPV) was noninferior to dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) in one phase 3 study (FLAIR) and to three-drug oral antiretroviral therapy (ART) more broadly in the companion ATLAS phase 3 study.
Novel injectable HIV therapy noninferlor to oral regimen
The same analysis linked 2 factors to higher bone mineral density: higher body mass index (a measure of weight) and longer treatment with HIV drugs in the integrase inhibitor class: raltegravir (also called Isentress), dolutegravir (also called Tivicay), and elvitegravir (one of the components of Stribild and Genvoya).
Bone density drops twice faster in middle-aged women than men with HIV
The correlations between viral suppression or continuous viral load (VL) levels with demographic factors, substance use, adherence, and integrase strand transfer inhibitor (ISTI) use were examined.
1997 to 2015 Saw Increase in HIV Viral Suppression Rates; Lower odds of having detectable viral load for older adults and those using ISTI-based regimen
It includes a fragment (named R4') inserted into the umuC gene, which is characterized by a phage integrase (ORF38) and a phage integrase family site-specific recombinase (ORF37) and encodes 9 genes from different origins with various functions.
Comparative Genomics Analysis of Plasmid pPV989-94 from a Clinical Isolate of Pantoea vagans PV989
The preferred regimens for starting treatment in the major international treatment guidelines have gradually moved towards an NRTI backbone of tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), tenofovir alafenamide/FTC (TAF/FTC) or abacavir/lamivudine (ABC/3TC) plus either the protease inhibitor (PI) darunavir (DRV) boosted by either ritonavir (r) or cobicistat (c), or the integrase inhibitors raltegravir (RAL), elvitegravir (ELV) or dolutegravir (DTG) or the non-nucleoside reverse transcriptase inhibitors rilpivirine (RPV) or efavirenz (EFV)--see EACS Guidelines.
2-Drug regimens in HIV treatment: pharmacological considerations
(2) These include the NRTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), PIs, a fusion inhibitor (FI), a CCR5 antagonist, and, more recently, integrase strand transfer inhibitors (INSTIs).
HIV update: which single-tablet regimens, and when
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