The company is also pursuing independent development of nacellins against
integrin alpha-4-beta-7 (IBD) and SMURF2 (fibrosis); its lead program seeks to develop orally bioavailable inhibitors of
integrin alpha-4-beta-7, which are safer and less immunogenic than marketed and investigational biologics targeting the same protein.
GBR 500 is an antagonist of the VLA2 (alpha2-beta1)
integrin.
When the outside part of the
integrin molecule binds to the matrix, a signal is sent inside the cell via a G protein, a type of protein involved in cell signalling but that was not previously known to interact with
integrins.
An introductory chapter on
integrin biology sets the stage for further discussion of the role that
integrins and associated proteins play in animal development; extracellular matrix assembly and cell migration (essential for organizing cells in tissues during embryogenesis and tissue repair); and regulation of intracellular signaling "cross-talk" cascades (that control cell differentiation and proliferation).
com/research/fb328e/alpha6_beta4_integ) has announced the addition of the "Alpha6 Beta4
Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011" report to their offering.
Increasing evidence underlays the essential role of lipid second messenger as important fine regulators of signaling cascade leading to
integrin affinity modulation.
By developing an innovative platform and directing it toward validated targets such as alpha-4-beta-7
integrin, Protagonist is emerging as an exciting company at the interface between molecular design and mucosal biology.
This time, they examined the cells for whether they contained
integrin, a protein that helps cells stick to each other.
LONDON, March 16 /PRNewswire/ -- Pharmaprojects, the leading database tracking pharmaceutical R&D worldwide, highlights a decreasing trend in the development of drugs targeting alpha4beta1
integrin (VLA-4).
IMGN388, a TAP compound, is designed to target and kill cells that express its v
integrin target.
The researchers say that, together, these molecules-called
integrin and netrin-may be a valuable new target in the efforts to halt cancer's spread via metastasis.
Acquires Worldwide Rights to Antibody to v5
Integrin --
