integrin

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integrin

[in′teg·rən]
(cell molecular)
A heterodimeric transmembrane receptor protein of animal cells that binds to components of the extracellular matrix on the outside of a cell and to the cytoskeleton on the inside of the cell, functionally connecting the cell interior to its exterior; in blood cells, integrins are also involved in cell-cell adhesion.
References in periodicals archive ?
The data clearly show that as stem cells move into their designated proliferating space, they ramp up integrin production.
Most of these receptors belong to integrin receptor family.
Cell spreading requires integrins to form cell-substratum adhesions that link the ECM to the actin cytoskeleton in order to regulate cell size and shape and initiate cell migration [10, 27-29].
Podocyte adhesion to the glomerular basement membrane is mainly modulated by integrins. Integrins are heterodimeric transmembrane receptor proteins, consisting of [alpha] and [beta] subunits, which mediate adhesion and interactions between cells and the extracellular matrix [8, 19].
TM4SF5 interacts with integrins [alpha]2, [beta]1 [18], and [alpha]5 [11]; EGFR [19]; TGF[beta]R [20]; and CD44 [7].
suPAR is a stable three-domain (D1, D2, and D3) protein that retains most of uPAR activities; both uPAR and suPAR are involved in the cell attachment, motility, and migration through their interaction with the integrins [90, 91].
Cheresh, "Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance," Trends in Cell Biology, vol.
The new organisation unites Antegrin's portfolio of small-molecule integrin antagonists with the drug-development expertise, seasoned executive experience, and track record of Cascadia.
Ligand binding to integrins. J Biol Chem 2000; 275: 21785-21788, doi: 10.1074/jbc.R000003200.
Integrins are proteins that 'integrate' the outside to the inside of the cell, providing a connection to the immediate external environment, and without them, almost every stage of the regenerative process is disrupted.
Researchers now think blocking the movement of integrins from outside to inside the cells could combat the disease spreading.
After taking pictures, expression of type IV collagen and integrins was measured by stained areas in three representative areas.

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