intercalated disc


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intercalated disc

[in′tər·kə‚lād·əd ′disk]
(histology)
A dense region at the junction of cellular units in cardiac muscle.
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Ghrelin Improves the Fine Structure of Atrial Natriuretic Factor (ANF) Granules and Intercalated Disc Junctions in Experimentally-Induced Myocardial Infarction in Rats
2 C and D), intact intercalated disc with clear identification of fully formed fascia adherence and desmosomes (Fig.
The sarcomere was clear with normal structures of intercalated disc and mitochondrial showing membrane integrity.
Objective: mXin[alpha], a downstream target gene of Nkx2.5 transcription factor, was shown to encode a proline-rich and Xin repeats-containing protein which localizes to the intercalated disc of adult hearts.
In all of the myocardial samples, segmentation of the myocardial cells at the intercalated disc level or widening of the cells at this level with bundles of distended myocardial cells alternating with bundles of contracted myocells was found.
The myocardial cells are disposed in columns, being kept together by specialized junctions, named intercalated discs. These junctions comprise cell-to-cell adhesion junctions composed of fascia adherens, gap junctions, and maculae adherentes (desmosomes).
In summary of the obtained results, we must point out that the devastating pathological changes in myocardial structure, especially in mitochondria, vacuolization of cytoplasm, enlargement of cell-organelle lumen (endoplasmatic reticulum, Golgi complex), enlargement of intercellular spaces within intercalated discs, and lack of glycogen granules in cytoplasm were found in rats submitted to the acute myocardial ischemia.
The cells are connected to each other end-to-end through highly specialised regions called the intercalated discs. Some cardiac myocytes may branch at the ends, and thereby join with two or more neighbouring cardiac myocytes.
As in the vertebrate myocardium, the cellular unit of molluscan heart muscle is a mononucleated muscle cell linked to its neighbors by intercalated discs (North, 1963; Watts et al., 1981; Okland, 1982; Kling and Schipp, 1987).
Subsequent microscopic analysis of the rabbits' hearts showed the transplanted cells had developed intercalated discs, "a distinctly cardiac feature" that is involved in transferring from cell-to-cell the electrical charge that powers the heartbeat, said investigator Doris Taylor, Ph.D.
It is codistributed with different types of intermediate filaments (IFs) and is prominently located at the plasma membrane attachment sites of IFs and of microfilaments, such as hemidesmosomes (Wiche et al., 1984), Z-line structures and dense plaques of striated and smooth muscle (Wiche et al., 1983), intercalated discs of cardiac muscle (Zernig and Wiche, 1985), and focal contacts (Seifert et al., 1992).