Construction of pDC316-mCMV-EGFP-dendritic cell-specific intercellular
adhesion molecule-3-grabbing nonintegrin
Bright green fluorescence at margin of cells in case of individual cells and in intercellular
region in case of group of cells was considered as positivity of smear for pemphigus vulgaris.
Having the ability to measure changes in tractions at the intercellular
level may serve as an early cancer-detection tool.
Gap junctions have intercellular
pores that facilitate the passage
(a) Hematoxylin and eosin staining showed moderately differentiated malignant cells with abundant cytoplasm connected with intercellular
TJs contain a complex of proteins spanning the intercellular
cleft (occludin and claudin) and junctional adhesion molecules [2, 20].
(20) These adaptive responses are probably regulated epigenetically and likely involve intra- and intercellular
Under normal conditions, ECs maintain the stable cytoskeleton system and effective intercellular
junctions to preserve normal barrier function, while many pathologic conditions can damage the stabilization of intercellular
junctions, subsequently resulting in endothelial hyperpermeability.
Table-2: Comparison of vessel involvement with intercellular
adhesion molecules levels.
The SEPEC cytotoxic factor causes elongation and loss of intercellular
junctions in Vero (African green monkey kidney epithelial) cells (data not shown), same as observed in HUVEC cells (Fig.
In pemphigus vulgaris, autoantibodies develop against intercellular
desmosomes (anti-desmoglein 3 in the mucosal variety), resulting in loss of cohesion of interepidermal cells followed by blistering and ulceration.
Loss of intercellular
bridges leading to acantholysis with few intact intercellular
bridges giving a deliapidated brick wall appearance.