Supporting features include the presence of reticular fibers surrounding individual cells, the absence of associated basement membrane material or intercellular junctions
, and the IHC profile of described cases.
enables visualization of intercellular junctions
Tissue-level interactions (contact inhibition of cell proliferation, exchange of signaling and regulatory molecules via intercellular junctions
, and secretion of regulatory factors by neighboring cells and stroma) are important in tumor suppression and control.
, numerous slender surface microvilli, and microvilli-lined lumina were observed [Figure 1]i,[Figure 1]k,[Figure 1]l.
Our previous studies demonstrated that disorders of cytoskeletons and intercellular junctions
led to higher pulmonary microvascular permeability.
The dense periodic material near the adherens junctions came apart under the same conditions, making it unlikely that it represents adhesive intercellular junctions
. Adhering junctions between dorsal epithelial cells also remained intact.
In this study, we observed that culture supernatant of all SEPEC strains isolated from patients with sepsis (HC/UNICAMP, Campinas, SP, Brazil), (3) were cytotoxic to human umbilical vein endothelial cells (HUVEC), causing loss of intercellular junctions
, cellular elongation and death.
The finding suggested that the traditional Chinese medicine DDD intervention, particularly early intervention of DDD, significantly ameliorated the injury of vascular endothelium, regulated intercellular junctions
of endothelial cells, changed the permeability of vascular endothelial cells, and eventually prevented vascular atherosclerosis.
A critical factor contributing to colitis disease progression is epithelial permeability that is controlled in large part by the stability of intercellular junctions
. Proinflammatory conditions contribute to the internalization of junctional proteins and destabilize epithelial cell contacts .
Dr Lydia Tabernero explains the results, "Scientists had always thought the reason for these incredibly strong connections was because the molecules were very rigid and structured as they are in other, weaker intercellular junctions
. However, when we isolated desmosome molecules and characterized them we found that they are actually much more flexible than those of the other junctions -- the total opposite to what people had thought!"
Sertoli cells were connected to each other by intercellular junctions
and they were adherent to the basement membrane by hemidesmosomes.
Chitosan nanoparticles (CNP) were used as the positive control because of their capacity to disrupt the tight intercellular junctions