interleukin-1


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interleukin-1

[‚in·tər¦lük·ən ′wən]
(immunology)
A cytokine produced by macrophages, endothelial cells, lymphocytes, and epidermal cells that plays roles in the inflammatory process and in the immune response. Abbreviated IL-1.
References in periodicals archive ?
Effect of the use of snuff on the levels of interleukin-1 beta and interleukin-8 in the gingival crevicular fluid of periodontitis patients.
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
Young, "A trial of recombinant human interleukin-1 in patients with severe refractory aplastic anaemia," British Journal of Haematology, vol.
King Professor of Internal Medicine, chair of the Department of Medicine, and professor of pathology, published in the Annals of Rheumatic Diseases, provide strong support for a central role of Interleukin-1 in the pathogenesis of OA.
Ethnicity greatly influences the interleukin-1 gene cluster (IL-1b promoter, exon-5 and IL-1 Ra) polymorphisms: a pilot study of a north Indian population.
Interleukin-1, interleukin-1 receptors, and interleukin-1 receptor antagonist.
(Rockville, MD) has patented human interleukin-1 .beta.
In US trials, patients scheduled for joint replacement surgery who received injections of cells drawn from their arthritic joints and genetically altered to manufacture the anti-inflammatory protein interleukin-1 receptor antagonist produced the protein for at least 4 weeks.
According to Amgen, Kineret (pending final clearance) would become the first drug to directly and selectively block interleukin-1 (IL-1), a protein present in excess quantities in RA patients that results in inflammation and joint damage.
Alternatively, elevated levels of tumor necrosis factor and interleukin-1 receptor antagonists on day two after vaccination (7) could be used to monitor the success of vaccinations by primary-care providers in remote areas in the United States (1) and elsewhere.
But according to researchers at the Massachusetts Institute of Technology (MIT), the solution may be found with a better understanding of how the chemical interleukin-1 affects joint cartilage.