interleukin-2


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Related to interleukin-2: Proleukin

interleukin-2

[‚in·tər¦lük·ən ′tü]
(immunology)
A lymphokine secreted mostly by helper T lymphocytes that promotes the growth of T lymphocytes. Abbreviated IL-2.
References in periodicals archive ?
Making interleukin-2 safer may prove more difficult since the motif falls in a region crucial to the protein's therapeutic function.
It's unprecedented," says Lane, who has worked on interleukin-2 therapy for 13 years.
For the treatment of hepatitis and cancer, Ceplene is administered in combination with cytokines such as interferon-alpha and interleukin-2, proteins that stimulate these same immune cells.
The article was entitled "Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma" (J Clin Oncol 2002; 20(1): 125-133).
Sobol of the San Diego Regional Cancer Center and his colleagues hoped that by inserting the gene that codes for interleukin-2 into mouse cells, they could produce cells that would secrete interleukin-2.
In the new experiment, he plans to eliminate the need for TIL cells by inserting genes for TNF or interleukin-2 directly into tumor cells removed from patients.
The title of the presentation is "Histamine and Interleukin-2 Inhibit Growth and Neovascularisation in Malignant Glioma.
Moreover, the experiment's protocol allows for the addition of some interleukin-2 later in the trials, depending on initial TNF-toxicity findings.
Strom and Murphy established that the insulitis-associated CD4 cells produce a chemical called interleukin-2 and also have surface receptors for it.
The planned renal cell carcinoma clinical trial is designed to evaluate Maxamine Therapy, consisting of the combination of Maxamine, Interferon Alfanative and interleukin-2 (IL-2), in the treatment of late-stage RCC patients in selected European sites.
An elevated level of serum interleukin-2 receptor is a sensitive screening test in Kawasaki's syndrome.
The alliance is expanded to cover all human cancer indications for gene medicines utilizing the genes for Interleukin-2 (IL-2), Interferon-alpha (IFN-alpha) and Interleukin-12 (IL-12).