proteins, or nanofilament proteins as they are sometimes called, are important stress proteins that in many cell types act as crisis command centers in times of cellular stress and emerge as interesting targets in many diseases.
aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization.
Keratin intermediate filament
(KRT-IF) is composed of type I and II keratins; a labeled keratin intermediate filament
type II (KIFII) gene was introduced into sheep and the wool quality obtained from transgenic sheep was significantly improved, with the wool fiber exhibiting high gloss and significant flexibility .
The Z-lines are the anchoring site of [alpha]-actinin, titin and several intermediate filaments
, including desmin and vimentin.
Distribution of vimentin-type intermediate filaments
in Sertoli cells of the human testis, normal and pathologic.
Goldman, "Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments
during mitosis," Molecular Biology of the Cell, vol.
This structure measures about 400 nm x 250 nm x 10 nm and anchors intermediate filaments
Folpe, "Aberrant intermediate filament
and synaptophysin expression is a frequent event in malignant melanoma: an immunohistochemical study of 73 cases," Modern Pathology, vol.
Neuronal intermediate filaments
and ALS: a new look at an old question.
This protein is one of the intermediate filaments
; create scaffold around the lines (Z) and attach them into the cell skeleton under the plasma membrane as well as keeps muscle fiber's sides together.
Therefore, in the present study, we examined the levels of costamere proteins, extracellular matrix components, and intermediate filaments
in order to determine 1) the morphological effects of intermittent passive manual stretching applied over 3 days on the soleus muscles of naive weanling rats, and 2) the extent of soleus muscle damage induced by intermittent passive manual stretching applied over 3 days in weanling rats whose hind limbs had been first immobilized in plantar flexion.
The presence of intermediate filaments
in Schwann cells, as seen in the ultrastructural examination, in previous studies, together with the electrophysiological findings showing an early decrease of sensory and motor nerve conduction velocities, suggest existence of a primary myelinic disorder associated with axonal damage as a cause of n-hexane neuropathy .