interstitial nephritis


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interstitial nephritis

[¦in·tər¦stish·əl nə′frīd·əs]
(medicine)
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Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly.
Acute renal failure induced by acute interstitial nephritis secondary to cocaine.
Studies dating back 25 years, however, demonstrate that proton pump inhibitors themselves can induce acute interstitial nephritis, which is a condition in which spaces between the kidney tubules become swollen and interfere with filtration of toxins out of one's blood.
Igarashi T, Itoh Y, Shimizu A, Igarashi T, Yoshizaki K, Fukunaga Y A case of juvenile Sjogren's syndrome with interstitial nephritis.
Acute Uses of some analgesics have been reported to interstitial be implicated in acute interstitial nephritis nephritis and with or without minimal change minimal-change glomerulopathy.
Arora suggested the reason PPIs might cause CKD is that over time, the kidneys might become damaged if patients suffer repeated bouts of acute interstitial nephritis, a form of tissue inflammation linked to short-term PPI use.
One case presented with rapidly progressive renal failure, with history of 10yrs Diabetes & absence of retinopathy, normotensive with no active urine sediment, in which biopsy suggestive of Acute tubule interstitial nephritis.
non-steroidal anti-inflammatory drugs (NSAIDs) can cause acute renal failure, interstitial nephritis and glomerulonephritis (Table 1).
Histopathology showed severe multifocal necrosis of liver and spleen (5/5), pulmonary congestion with macrophage infiltration in air capillaries (5/5), discrete interstitial nephritis (2/2), superficial necrosis of the intestinal mucosa with large numbers of coccobacilli (2/2), moderate peritonitis (2/2), and discrete airsacculitis (1/1).
Of the 4 variants, the tubulopathy associated with the interstitial inflammatory reaction (acute tubular interstitial nephritis variant) was the most prevalent (n = 28 or 49% of all cases with proximal tubulopathy; Table 2), followed by the proximal tubulopathy without cytoplasmic inclusions (acute tubular necrosis variant) (n = 22, 39% of all cases; Table 1), proximal tubulopathy with cytoplasmic inclusions in proximal tubular cells (4 cases; approximately 8%; Table 3), and 3 cases (5% of all cases) with the "lysosomal indigestion/constipation" variant (Table 4).
Clinical tests conducted on users of various anabolic steroids showed that they can cause numerous health problems such as liver diseases, interstitial nephritis, intestinal and respiratory disorders and hair loss.
Rarely, treatment with meglumine antimoniate can cause AKI due to interstitial nephritis.

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