intervening sequence


Also found in: Dictionary, Thesaurus, Medical, Legal, Acronyms.
Related to intervening sequence: lariat

intervening sequence

[¦in·tər¦vēn·iŋ ′sē·kwəns]
(genetics)
The one or more segments of a split gene that are transcribed but not included in the final messenger ribonucleic acid; each is flanked by two exons. Also known as intron.
Mentioned in ?
References in periodicals archive ?
Splice site variant c.2988+1G>A (legacy name, c.3120+1G>A, intervening sequence 16) illustrates this concept well.
(b) Known polymorphism in HFE intervening sequence (intron) 2 (IVS2) (39).
We examined previously reported common mutations in Indian populations, i.e., Codon 15 (G [right arrow] A), intervening sequence (intron)-I-1 (G [right arrow] T) [IVS-I-1 (G [right arrow] T)], IVS-I-5 (G [right arrow] C), Codon 8/9 (+G), and Codon 41/42 (-TCTT); two rare mutations, Codon 30 (G [right arrow] C) and IVS-I-1 (G [right arrow] A); and the mutations producing the hemoglobin variants [[beta].sup.E] [Codon 26 (GAG [right arrow] AAG)] and [[beta].sup.s] [Codon 6 (GAG [right arrow] GTG)] by reverse dot-blot (RDB) analysis (3).
In cases where tRNAs are the intervening sequences they may serve as signals for processing larger transcripts from which proteins are translated (Battey and Clayton, 1981; Ojala et al., 1981).