intracellular enzyme


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intracellular enzyme

[¦in·trə′sel·yə·lər ′en‚zīm]
(biochemistry)
An enzyme that remains active only within the cell in which it is formed. Also known as organized ferment.
References in periodicals archive ?
Three intracellular enzymes viz, oxidase, catalase and urease were studied in all isolates and nitrate reduction tests was studied only for Bacillus species.
The mechanism of action of finasteride is to inhibit the steroid 5-alpha reductase, which is an intracellular enzyme that converts testosterone into the potent androgen 5-alpha dihydrotestosterone (DHT).
PhaseRx is a biopharmaceutical company dedicated to developing mRNA products for the treatment of children with inherited enzyme deficiencies in the liver using intracellular enzyme replacement therapy (i-ERT).
According to the company, PRX-OTC is an intracellular enzyme replacement therapy (i-ERT) designed to replace the missing or defective enzyme inside the cells of patients with OTCD.
The intracellular enzyme activity was observed under wide ranges of pH (5-9), temperature (30degC-90degC) and metal ions (Na+, Mg2+, Mn2+, Zn2+ and Cu2+).
Purification and characterization of an intracellular enzyme with beta-glucosidase and beta-galactosidase activity from the thermophilic fungus Talaromyces thermophilus CBS 236.58.
D-Amino acid Oxidase is intracellular enzyme. The acetone disrupts the cell membranes and the enzyme extudes out.
tTG, an intracellular enzyme, has recently been proposed as the major autoantigen of anti-endomysial antibodies (EMAs), and measurements of IgA anti-tTG antibodies are used in the diagnostic evaluation of celiac disease (CD) (2-4).
The mechanism of action of these compounds is novel and involves, among many findings, the activation of a specific phosphatase, a specific intracellular enzyme.
Regenacy's lead clinical candidate, ricolinostat (ACY-1215), and the non-clinical proof-of-concept compound, ACY-1083, each selectively inhibit the intracellular enzyme HDAC6, a histone deacetylase that is known to have specificity for cytoplasmic, non-histone cellular proteins.
Acetylon said that selective inhibition of the intracellular enzyme HDAC6 may offer enhanced anti-cancer effectiveness through potentially reduced side effects and improved tolerability compared to current non-selective inhibitors, which are active against both Class I and Class II HDACs.

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