intracellular enzyme


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intracellular enzyme

[¦in·trə′sel·yə·lər ′en‚zīm]
(biochemistry)
An enzyme that remains active only within the cell in which it is formed. Also known as organized ferment.
References in periodicals archive ?
Rocilinostat (ACY-1215) selectively inhibits the intracellular enzyme HDAC6, leading to inactivation of the "aggresome" pathway for degradation of damaged proteins.
According to the company, PRX-OTC is an intracellular enzyme replacement therapy (i-ERT) designed to replace the missing or defective enzyme inside the cells of patients with OTCD.
tTG, an intracellular enzyme, has recently been proposed as the major autoantigen of anti-endomysial antibodies (EMAs), and measurements of IgA anti-tTG antibodies are used in the diagnostic evaluation of celiac disease (CD) (2-4).
The mechanism of action of these compounds is novel and involves, among many findings, the activation of a specific phosphatase, a specific intracellular enzyme.
Selective inhibition of the intracellular enzyme HDAC6 may provide enhanced anti-cancer effectiveness through potentially reduced side effects and improved tolerability compared to current non-selective inhibitors, which are active against both Class I and Class II HDACs.
Regenacy's lead clinical candidate, ricolinostat (ACY-1215), and the non-clinical proof-of-concept compound, ACY-1083, each selectively inhibit the intracellular enzyme HDAC6, a histone deacetylase that is known to have specificity for cytoplasmic, non-histone cellular proteins.
Acetylon said that selective inhibition of the intracellular enzyme HDAC6 may offer enhanced anti-cancer effectiveness through potentially reduced side effects and improved tolerability compared to current non-selective inhibitors, which are active against both Class I and Class II HDACs.
CPA and IFOS are pro-drugs that cannot kill cells unless activated by an intracellular enzyme (aldehyde dehydrogenase 3A1; ALDH).
The claims of this issued patent describe methods of isolating adult stems from various sources - including human bone marrow, peripheral blood and cord blood - based on the elevated expression of an intracellular enzyme, aldehyde dehydrogenase (ALDH), as a key stem cell marker.
Aldehyde dehydrogenase (ALDH) is an intracellular enzyme found in stem and progenitor cells.

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