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A growth pattern of epithelial tumors in which the proliferating epithelial cells grow outward from a surface, accompanied by vascularized cores of connective tissue, to form a branching structure.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a benign tumor of man and animals; its basic structural element is a connective-tissue papilla covered with epithelium and containing vessels. The growth of the papillae in various directions sometimes gives a papilloma the appearance of a cauliflower. The presence of numerous papillomas is called papillomatosis. Papillomas are most commonly found on the skin, although they sometimes occur on mucous membranes. In man, they may be congenital or may result from chronic inflammatory irritation. Some papillomas are viral in origin, for example, those of the sexual organs. The recommended therapy is surgical removal.

Papillomatosis in animals is caused by locally specific viruses. It affects cattle, horses, dogs, and rabbits and occasionally goats, sheep, and wild animals. The infection is caused by diseased animals; natural infection results from contact between diseased and healthy animals. The disease is long in duration. Isolated coral-like papillomas appear and then spread. Their surface is dry, horny, and cracked. When injured, papillomas bleed and become infected and ulcerous. Diagnosis is based on clinical and histological examination. Treatment generally consists of surgical removal.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The densely cellular neoplastic cells often appear to be streaming, and thus may be mistaken for intraductal papilloma with florid ductal hyperplasia.
Most AMEs have papillary configuration and, therefore, have been considered a variant of intraductal papilloma by some authors or a morphologic evolution from intraductal papilloma (Figure 1, A).
Intraductal papilloma of the male breast: an ultrastructural and immunohistochemical study.
In only a single patient (0.2%), additional levels were required to make the diagnosis of intraductal papilloma, but even in this case the papilloma was so small (0.15 cm) that it disappeared on further sections, was probably an incidental finding, and thus did not warrant further treatment.
Rizzo et al (17) advocated surgical excision of all intraductal papillomas identified on core needle biopsies because of an upgrade of almost a fourth of these lesions caused by the presence of either atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS) on subsequent surgical excision.
An intraductal papilloma is a benign, or noncancerous, breast tumour that forms in a milk duct and is made of gland and fibrous tissue as well as blood vessels.
Atypical ductal hyperplasia may secondarily involve benign breast lesions, including intraductal papillomas, fibroepithelial lesions, radial scars, and adenosis.
The pathological examination showed that one patient had ductal carcinoma in situ (20.0%), two had intraductal papilloma, and two had cystic disease of the breast.
Those patients with a core biopsy diagnosis of atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), radial scar formation (RS), or intraductal papilloma (PAP) were referred to a breast surgeon for excision.
Here we present a case of osteogenic sarcoma arising in an intraductal papilloma of the breast.
The recent WHO classification of tumours of the breast (2012) subdivides intraductal papillary lesions into 4 categories; Intraductal papilloma, intraductal papillary carcinoma, encapsulated papillary carcinoma and solid-papillary carcinoma.1
Mammography imaging characteristics of breast cancer in different pathological types: One hundred forty nine cases were diagnosed as benign lesion, including 75 cases of adenoma, 48 cases of adenoma fibrosum (Fig.1), 14 cases of intraductal papilloma, three cases of mammitis, two cases of lipomyoma, two cases of phyllodes tumors, two cases of cyst (Fig.2), one case of granulomatous inflammation, 1 case of hyperplasia of mammary glands and 1 case of abscess.

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