As has previously been noted for TP53, the presence of somatic mutations within FBXW7, PIK3CA, and PPP2R1A in serous
intraepithelial carcinoma and concurrent serous endometrial carcinomas implicates mutation of these genes as early events in the development of serous endometrial cancer (16).
Although most of these occult carcinomas involve the tubal fimbriae, and are tubal
intraepithelial carcinomas (TICs), (2-4) other sites, such as the midportion of the isthmus, are also involved.
In 1961, Abell and Gosling [55] described 2 distinct histopathologic types as
intraepithelial carcinoma of Bowen's type and
intraepithelial carcinoma simplex type.
Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship.
By applying the criteria used to classify ovarian mucinous cystic neoplasms, these areas were designated as foci of
intraepithelial carcinoma, on the basis of the presence of severe cytologic atypia.
14-16) Figure 3, A and B, illustrates a typical example of a small focus of endometrial
intraepithelial carcinoma in an atrophic curettage specimen.
