In addition, synchronous occurrence of intraepithelial carcinoma
was also noted in the endometrium with continuous and skip patterns and in the tube with partial lesions.
Incidental serous tubal intraepithelial carcinoma
and early invasive serous carcinoma in nonprophylactic setting: analysis of a case series.
As has previously been noted for TP53, the presence of somatic mutations within FBXW7, PIK3CA, and PPP2R1A in serous intraepithelial carcinoma
and concurrent serous endometrial carcinomas implicates mutation of these genes as early events in the development of serous endometrial cancer (16).
Hematoxylin-eosin images showing the morphologic spectrum of primary mucinous cystic tumors of the urachus, including (A, B) mucinous cystadenoma; (C, D) mucinous cystic tumor of low malignant potential (MCTLMP); (E, F) intraepithelial carcinoma
(IEC); and (G, H) invasive cystadenocarcinoma.
The possibility that a tubal intraepithelial carcinoma
could represent a metastasis should be considered by practicing pathologists even in the context of HGSC.
Serous endometrial intraepithelial carcinoma
(A) and serous endometrial carcinoma (C) show strong, diffuse nuclear immunoreactivity with p53 in most cases (B and D) (hematoxylin-eosin, original magnification X10 [A and C]; original magnifications X4 [B] and X10 [D]).
Serous Carcinoma In Situ Versus Benign/Reactive Endometrium.--Serous intraepithelial carcinoma
of the endometrium is considered an early form of malignancy with an approximately 5% risk of recurrence following surgical staging.
Endometrial intraepithelial neoplasia should never be confused with endometrial intraepithelial carcinoma
, which refers to serous carcinoma and is driven by a p53 mutation.
Some cases contained foci of endometrial intraepithelial carcinoma
. A background of scant and atrophic endometrial epithelium could be appreciated in 5 of the 18 cases (28%).
Subsequent descriptions of the "earliest histologic changes of cervical cancer" as surface carcinoma or intraepithelial carcinoma
, and later carcinoma in situ (CIS), reflected the histologic descriptions of cells that morphologically looked like cancer but had not invaded below the basement membrane [17-19].
In contrast to type I tumors, type II tumors are rarely associated with morphologically recognizable precursor lesions; however, type II tumors may arise from "dysplasia" in inclusion cysts or serous intraepithelial carcinoma
in the fallopian tubes.
(18) The spectrum of mucinous cystic neoplasms involving the renal pelvicalyceal system is similar to the more common ovarian mucinous neoplasms and includes benign mucinous cystadenoma, mucinous borderline tumor with or without intraepithelial carcinoma
, and mucinous cystadenocarcinoma.