In addition, synchronous occurrence of
intraepithelial carcinoma was also noted in the endometrium with continuous and skip patterns and in the tube with partial lesions.
Incidental serous tubal
intraepithelial carcinoma and early invasive serous carcinoma in nonprophylactic setting: analysis of a case series.
As has previously been noted for TP53, the presence of somatic mutations within FBXW7, PIK3CA, and PPP2R1A in serous
intraepithelial carcinoma and concurrent serous endometrial carcinomas implicates mutation of these genes as early events in the development of serous endometrial cancer (16).
Hematoxylin-eosin images showing the morphologic spectrum of primary mucinous cystic tumors of the urachus, including (A, B) mucinous cystadenoma; (C, D) mucinous cystic tumor of low malignant potential (MCTLMP); (E, F)
intraepithelial carcinoma (IEC); and (G, H) invasive cystadenocarcinoma.
The possibility that a tubal
intraepithelial carcinoma could represent a metastasis should be considered by practicing pathologists even in the context of HGSC.
Serous endometrial
intraepithelial carcinoma (A) and serous endometrial carcinoma (C) show strong, diffuse nuclear immunoreactivity with p53 in most cases (B and D) (hematoxylin-eosin, original magnification X10 [A and C]; original magnifications X4 [B] and X10 [D]).
Serous Carcinoma In Situ Versus Benign/Reactive Endometrium.--Serous
intraepithelial carcinoma of the endometrium is considered an early form of malignancy with an approximately 5% risk of recurrence following surgical staging.
Endometrial intraepithelial neoplasia should never be confused with endometrial
intraepithelial carcinoma, which refers to serous carcinoma and is driven by a p53 mutation.
Some cases contained foci of endometrial
intraepithelial carcinoma. A background of scant and atrophic endometrial epithelium could be appreciated in 5 of the 18 cases (28%).
Subsequent descriptions of the "earliest histologic changes of cervical cancer" as surface carcinoma or
intraepithelial carcinoma, and later carcinoma in situ (CIS), reflected the histologic descriptions of cells that morphologically looked like cancer but had not invaded below the basement membrane [17-19].
In contrast to type I tumors, type II tumors are rarely associated with morphologically recognizable precursor lesions; however, type II tumors may arise from "dysplasia" in inclusion cysts or serous
intraepithelial carcinoma in the fallopian tubes.
(18) The spectrum of mucinous cystic neoplasms involving the renal pelvicalyceal system is similar to the more common ovarian mucinous neoplasms and includes benign mucinous cystadenoma, mucinous borderline tumor with or without
intraepithelial carcinoma, and mucinous cystadenocarcinoma.