intragenic


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intragenic

[¦in·trə¦jen·ik]
(cell and molecular biology)
Within a gene, in referring to certain events.
References in periodicals archive ?
However, although most of the SM-DMRs were detected in multiple cell types, including saliva cells, phenotypic differences in responses between cell types suggest that both smoking-altered methylation and eRNA production from the intragenic AHRR enhancer may be necessary preconditions for cell type-specific AHRR transcription.
A heterozygous microdeletion at chromosome 9q34.3 overlapping the euchromatin histone methyltransferase 1 (EHMT1) gene accounts for more than 75% of cases, and the remainder are associated with a heterozygous intragenic pathogenic variant in the EHMT1 gene [1, 2].
Large intragenic deletions in the FBN1 gene have been detected in approximately 2% of individuals with MFS who did not have a pathogenic variant identified by sequence analysis [14].
Kalinin, "Molecular genetic analysis of TUB18 and TUB20 intragenic polymorphism and various mutations of the CFTR gene in the Moscow region," Genetika, vol.
Cohen syndrome resulting from a novel large intragenic COH1 deletion segregating in an isolated Greek island population.
Cytosines at a CpG dinucleotide are either methylated (5-mC) or unmethylated, but nonpromoter CpGs, including those at intragenic CpG sites of transcribed genes, are generally methylated.
Linkage analysis: Three intragenic RFLPs were studied in all the study participants.
Such contingency loci are directly involved in interaction with host components and are frequently subjected to polymerase slippage to generate phenotypic variation for survival in adverse environmental conditions.6 These SSRs are reported to be associated with pathogenic bacteria adaptation and virulence such as Bordetella pertussis, Campylobacter jejuni, Helicobacterpylori, Haemophilus influenzae and Neisseria meningitides.2,7,8 SSRs present within the coding region of a gene known as Intragenic SSRs can cause frame-shift mutation within coding sequences and thus can affect its translation and lead to premature termination of translation or altered protein C terminal.
Grogan, "Characterization of intragenic recombination in a hyperthermophilic archaeon via conjugational DNA exchange," Journal of Bacteriology, vol.
Intragenic regions of six virulence genes (clpP, dal, inlB, inlC, lisR, andprfA) were amplified and sequenced by IGA Technology Services (Udine, Italy), using ABI 3730XL DNA analyser.
[19] also identified numerous TNF[alpha]-responsive and NF-[kappa]B-regulated factory eRNAs at intergenic and intragenic enhancers or HUVEC-specific SEs.