intrathecal

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intrathecal

[¦in·trə′thē·kəl]
(anatomy)
Within the subarachnoid space.
References in periodicals archive ?
When the treatment of shunt infections with intravenous antibiotics is unsuccessful, antibiotics may be intrathecally administered.
Our primary objective was to determine the duration of analgesia, secondary objective was to evaluate the onset of sensory and motor blockade, quality of analgesia, s adjuvants used intrathecally.
In the mechanical withdrawal threshold testing, groups of rats were injected intrathecally with saline, najanalgesin, or SP600125; the paw withdrawal threshold was measured for 24 h after injection.
Respiratory rate decreased significantly with all three doses of xylazine and returned to normal after 90 105 and 120 minutes with 6 8 and 10 mg/kg respectively Similar effects of xylazine have been reported by Nolan and Erhardt (1990) who reported that a2 agonist xylazine produced a dose-dependent decrease in mean arterial blood pressure in conscious rabbits when injected intrathecally through a cannula previously implanted under general anaesthesia.
Devices such as implanted pumps are used for delivery of drugs such as opioids intrathecally (introduction into spinal subarachnoid space by lumbar puncture) in patients with cancer pain.
They are done both intravenously and intrathecally (into the spinal canal).
7), (8) Boschi et a1 (13) found that antipsychotics cause hypothermia in rats when the drug is administered intraperitoneally but not when given intrathecally.
Taguchi et al8 have shown that in 10 patients with cancer pain in whom small-dose of betamethasone was used intrathecally once a week, sufficient pain relief was achieved in about a half of patients and no clinical complications were reported.
After prehydration, the fluid infusion was continued at minimal rate to maintain vein patency, regardless of any haemodynamic changes with the patient in the left lateral position, 2 mL of 5% hyperbaric lidocaine was injected intrathecally at L4-5 via a 27-gauge Quincke spinal needle.