globulin

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Related to intravenous immune globulin: Intravenous immunoglobulin

globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.
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Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
The objective of the study was to compare the therapeutic efficacy of Intravenous immune globulin (IVIG) with plasma exchange in patients of acute post infectious polyneuropathy (Guillain-Barre syndrome).
Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy.
Controlled trial to evaluate protection of high-risk infants against respiratory syncytial virus disease by using standard intravenous immune globulin. Antimicrobial Agents and Chemotherapy, 37, 1655-1658.
Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011; 365: 1201-11.
Among the factors favoring the use of intravenous immune globulin (IVIG) for postexposure prophylaxis is the fact that it usually is in ample supply,, said Philip LaRussa, M.D., of the division of pediatric infectious diseases, Columbia Presbyterian Medical Center, New York City.
Among the factors favoring the use of intravenous immune globulin (IVIG) for postexposure prophylaxis is the fact that it usually is in ample supply, although there have been some shortages in the past, said Philip LaRussa, M.D., of the division of pediatric infectious diseases, Columbia Presbyterian Medical Center, New York City.
Treatment with antibiotics and corticosteroids was ineffective, but infusions of intravenous immune globulin and high-dose aspirin led to symptom resolution.
Warnings about the risk of thrombotic events in patients who receive human intravenous immune globulin have been issued by the American Red Cross and Baxter Healthcare Corp.
Intravenous immune globulin also has been used in treatment, and anecdotal reports suggest that there have been good outcomes, Dr.
RSV intravenous immune globulin and a recently licensed, humanized murine anti-RSV monoclonal antibody are available as prophylaxis for serious RSV infections in some high-risk infants and young children (e.g., those born prematurely or with chronic lung disease) (7).
Several years ago, a small open study of intravenous immune globulin found significant improvements in eye contact, speech and verbal behavior.
The panel strongly rejected facilitated communication, auditory integration training, and intravenous immune globulin, citing evidence that they may actually cause harm.

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