globulin

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Related to intravenous immune globulin: Intravenous immunoglobulin

globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
The objective of the study was to compare the therapeutic efficacy of Intravenous immune globulin (IVIG) with plasma exchange in patients of acute post infectious polyneuropathy (Guillain-Barre syndrome).
Controlled trial to evaluate protection of high-risk infants against respiratory syncytial virus disease by using standard intravenous immune globulin.
RI-001 is a plasma-derived, polyclonal, intravenous immune globulin with standardized high levels of antibodies against respiratory syncytial virus ("RSV").
Further information Thromboembolic events, including stroke, myocardial infarction, pulmonary embolism and deep vein thrombosis have been observed with all intravenous immune globulin products through published literature and post-marketing surveillance.
Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial.
The nation's largest distributor of human plasma products and influenza vaccines, FFF's successful counterfeit-free record translates into more than 120 million grams of intravenous immune globulin and 70 million doses of influenza vaccine administered to patients through the company's secure pharmaceutical supply channel.
Such patients should only receive intravenous immune globulin with utmost caution and in a setting where supportive care is available for treating life-threatening reactions.
Eight people in the United States, including one in California, are reported by patient advocates to have died due to lack of access to the human plasma product, intravenous immune globulin (IVIG).
Seven people in the United States are reported by patient advocates to have died due to lack of access to the human plasma product, intravenous immune globulin (IVIG).
Melvin Berger, Children's Research Foundation of Cleveland, Cleveland, Ohio: "Subcutaneous versus intravenous immune globulin treatment in animal models of neuromuscular disease.
Abdul Razzaque Ahmed, Zachary Spigelman, Lisa Cavacini and Marshall Posner reported on their use of rituximab and intravenous immune globulin in patients with recalcitrant pemphigus vulgaris.
Representatives Jim McCrery (R-LA), Mark Foley (R-FL) and Steve Israel (D-NY) have collected 55 colleagues' signatures on a letter to Health and Human Services Secretary Mike Leavitt, urging him to declare a public health emergency so patient access to intravenous immune globulin (IVIG) crisis can be resolved.

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