intrinsic factor


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intrinsic factor

[in′trin·sik ¦fak·tər]
(biochemistry)
A substance, produced by the stomach, which combines with the extrinsic factor (vitamin B12) in food to yield an antianemic principle; lack of the intrinsic factor is believed to be a cause of pernicious anemia. Also known as Castle's intrinsic factor.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
According to Tables 3 & 5, four factors were concluded Income Factor, Independence Factor, Intrinsic Factor and Family Security Factor, similar to what was concluded by Benzing, Chu and Kara (2009) where they found also four factors; Income Factor, Security Factor, Independence factor and Intrinsic Factor, but with different loadings.
First, it makes some sense from a pathophysiologic standpoint, as intrinsic factor is needed to absorb the small amounts of vitamin [B.sub.12] in our usual diets.
It is possible that a false normal vitamin B12 level may have been caused by interference from a high-titer of intrinsic factor antibody [8].
Serum Holotranscoblamine II (Active B12) was measured by fully automated AxSYM-Abbott Diagnostics chemiluminescent microparticle immunoassay (CMIA) for quantitative determination of Holotranscoblamin in human serum on Architect System (3P2425).6 Serum IF antibodies were measured by Quanta Lite TM Intrinsic Factor ELISA (708780) INOVA using Diasorin ETI-max 3000 (Via Crescentino SNC 13040 Saluggia (VC) Italy).7 Serum GPC antibodies were measured by indirect immunofluorescence on mouse-stomach sections (NOVA Lite(R) ANA Plus).8
Older patients have poorer stomach acid production and are frequently prescribed proton pump inhibitors, which stop the stomach from secreting hydrochloric acid intrinsic factor. They may be taking other drugs for pre-existing medical conditions like histamine-[H.sub.2] blockers, antacids, or metformin, a commonly prescribed drug for diabetes, which causes a disturbance in the ileum in the small intestine for the receptors to transfer vitamin [B.sub.12] in the body.
While the extrinsic motivation provided by the grading system may stimulate greater effort by some students, others may be motivated by intrinsic factors. The goal of this study is to provide new evidence on the importance of grades in motivating students to complete coursework.
The free vitamin then binds with a glycoprotein, intrinsic factor (IF), originating from the gastric parietal cells.
Pernicious anemia is a form of anemia that occurs when there is an absence of intrinsic factor, a substance normally present in the stomach.
The intrinsic factor indicated to what extent coaching is engaged in due to fun or enjoyment motives.
It is due to the malabsorption of Vitamin B12 resulting from lack of special factor called Intrinsic Factor, which the body needs to absorb the vitamin from food.
It is presented as an intrinsic factor in the model.
It is then bound by intrinsic factor and transported from the proximal ileum to the distal ileum, where it is then bound to transcobalamin II for transport to the liver and bone marrow.