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Any one of a family of enzymes, also known as hyaluronate lyases or spreading factors, produced by mammals, reptiles, insects, and bacteria, which catalyze the breakdown of hyaluronic acid. Some hyaluronidases also attack other similar polysaccharides. Since all liquefy the polysaccharide gel which fills the tissue spaces, they effectively accelerate diffusion so that injected, dissolved, or particulate matter (bacteria, viruses, toxins, or pigments) can diffuse through a larger volume of tissue. See Hyaluronic acid

The biological importance of the enzyme depends upon its source. That found in the culture filtrates of many strains of virulent bacteria permits the microorganisms to gain access to a larger volume of the host's tissue and, hence, to additional nutriment. That found in the venom of certain snakes and bees permits the toxin to produce more extensive damage to the victim. See Enzyme


Any one of a family of enzymes which catalyze the breakdown of hyaluronic acid. Also known as hyaluronate lyase; spreading factor.
References in periodicals archive ?
The warm environment enables RovA to alter its form and de-activates the gene for invasin production.
By binding to those bacterial surface receptors, Isberg's team found, invasin switches on reactions in host cells that probably rearrange the network, in effect opening the door.
Apparently, the presence of invasin and Yop1 results in a mild, controlled infection but their absence allows bacteria to ravage cells and cause disease, the researchers say.
Given the collective data on both adhesins, it seems that MTP may be a marginally better adhesin than HBHA and that the latter may, in turn, be more effective as an invasin compared with the former.
Invasin apparently has roles both in binding bacteria to cells and in expediting their subsequent entry.
Neisseria meningitidis adhesin NadA targets [31 integrins: functional similarity to Yersinia invasin.
pyogenes and SDSE in human hosts because it acts as an adhesin, invasin, and antiphagocytic factor (11).
Invasin is the primary requirement for efficient translocation of the bacteria across the intestinal epithelium; the identification of both positive and negative regulators of its expression have been identified.
Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene.
Staphylococcus aureus pathogenesis; secretion systems, adhesins, and invasins.
sup][3] Morphological transition between yeast and hyphal forms, expression of adhesins and invasins on the cell surface, production of tissue-damaging hydrolytic enzymes (e.