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A growth pattern of epithelial tumors in which the proliferating epithelial cells grow outward from a surface, accompanied by vascularized cores of connective tissue, to form a branching structure.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a benign tumor of man and animals; its basic structural element is a connective-tissue papilla covered with epithelium and containing vessels. The growth of the papillae in various directions sometimes gives a papilloma the appearance of a cauliflower. The presence of numerous papillomas is called papillomatosis. Papillomas are most commonly found on the skin, although they sometimes occur on mucous membranes. In man, they may be congenital or may result from chronic inflammatory irritation. Some papillomas are viral in origin, for example, those of the sexual organs. The recommended therapy is surgical removal.

Papillomatosis in animals is caused by locally specific viruses. It affects cattle, horses, dogs, and rabbits and occasionally goats, sheep, and wild animals. The infection is caused by diseased animals; natural infection results from contact between diseased and healthy animals. The disease is long in duration. Isolated coral-like papillomas appear and then spread. Their surface is dry, horny, and cracked. When injured, papillomas bleed and become infected and ulcerous. Diagnosis is based on clinical and histological examination. Treatment generally consists of surgical removal.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Surgery is primarily used for the management of inverted papilloma of the middle ear and mastoid cavity.
A study on the clinical profile and management of inverted papilloma. Indian J Otolaryngol Head Neck Surg.
Barnes, "Management of inverted papilloma," The Laryngoscope, vol.
Inverted papillomas and benign nonneoplastic lesions of the nasal cavity.
Management of inverted papilloma. Laryngoscope 1990;100:481-90.
Papillomas arising from this membrane is very unique, in that they are found to be growing inwardly and hence the term inverted papilloma. Inverted papillomas behave like neoplasms, arising from reserve/ replacement cells located at the basement membrane of the mucosa.
Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol 2009;3:260-2
Local pain was observed in cases of malignancy and inverted papilloma with secondary infection.
Inverted papilloma is a rare benign neoplasm that usually originates in the lateral nasal wall.
The nested areas of our lesion suggested a differential diagnosis with inverted papilloma, papillary urothelial neoplasm of low malignant potential, and lowgrade urothelial carcinoma.