A schematic of the ion current
sensing circuit is reported in Figure 1.
With the help of the battery, ion current
is supplied through the electrodes of the patch, and oxidation takes place on one of them, and reduction takes place on the other where ions of the other polarity are collected.
Representative total ions current from mixed quality control samples is shown in [Supplementary Figure 2 [SUPPORTING:2]]a and [Supplementary Figure 2]b, revealing the intensity of ion current
. Multiple peaks from mixed samples present all the detected metabolites, and each spectrum peak represents a detected metabolite.
Meech's Ion Current
Monitoring (ICM) technology ensures performance is maintained.
where v is the voltage; C is the capacitance; [r.sub.s] designates the resistance determined as 1/([pi][[alpha].sup.2][ [sigma].sub.1]), where a is the radius of an axon and [[sigma].sub.1] is the conductivity; and [I.sub.i] is the ion current
. Standard notations x = distance along the fibre and t = time are used.
This implies that if the polarization originates from the ion migration in the insulator, then the variation of the electric current in the external circuit equals the one of the ion current
, that is, the oxygen vacancies arrive at the cathode and contribute to the electric current in the external circuit, but do not capture the electrons.
Similarly, recent studies have shown that the ion current
in a constant volume chamber and HCCI engines can be explained well by using equilibrium assumptions and that [H.sub.3][O.sup.+] is indeed the dominant positive ion [17, 18].
The total ion current
chromatogram and mass spectra of the NMOR derivative are shown in Figure 2.
Although the atrial-selective ion current
[I.sub.[K.sub.ACh]] has recently been reported in human embryonic stem cell-derived atrial-like CMs , [I.sub.[K.sub.ACh]] has not been studied in hiPSC-CMs.
The overlay of the total ion current
(TIC) suggests the analysis is very reproducible between injections.
The energy consumed by a neuron can be measured by the joule heat transformed from electric potential energy, so that we can calculate this energy consumption from membrane potential, Nernst potential, and ion current
. Most metabolic energy released by ATP is provided to the [Na.sup.+]/[K.sup.+] pump, so energy consumed by the [Na.sup.+]/[K.sup.+] pump could represent the energy supply to a neuron.
That is, negative feedback in electric autapse can suppress the fluctuation of membrane potential and then the ion current
of [Ca.sup.2+]; as a result, the concentration of [IP.sub.3] is also decreased completely.