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Localized tissue anemia as a result of obstruction of the blood supply or to vasoconstriction.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a local deficiency of blood; insufficient blood in an organ or tissue because of the narrowing or complete occlusion of the lumen of an afferent artery.

Transitory ischemia (like hyperemia) may result from physiological regulation of the blood supply, such as in reflex spasm of an artery caused by a mental factor (fright); the influence of pain, cold, chemical substances (epinephrine, ergotin), and biological stimuli (bacteria, toxins); the obstruction of an artery by a thrombus or embolus; constriction of the lumen of a blood vessel in connection with an atherosclerotic or inflammatory process in the wall; or compression of an artery by a tumor, scar, or foreign body. The aftereffects of ischemia depend on the degree of disruption of the blood flow, the rate of development and duration of the ischemia, the sensitivity of the tissue to oxygen deficiency, and the general condition of the body. Ischemia may end in complete restoration of the structure and function of the affected organ or tissue, but it also may lead to necrosis (infarct). The central nervous system and heart muscle are particularly sensitive to ischemia.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
"Given the modest effect size, choice of antidepressant treatment should be based on effectiveness and adverse events such as weight gain rather than the risk of arterial ischemic events," the authors write.
PMZ-1620 has the potential to be a first-in-class neuronal progenitor cell therapeutics with anti-apoptotic activity that improves cerebral blood flow and neurological outcome in cerebral ischemic stroke patients, according to the company.
During 14 years of follow-up, 101 participants had incident strokes, 87 of which were ischemic strokes.
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Thus, dynamic thiol-disulfide homeostasis is achieved.9 Despite the inflammatory process observed following a stroke and the antioxidant process that develops in response to the consequential ischemic neuronal damage, very little is currently known about the process of the antioxidants, although increasing evidence of abnormal TDH following disease has been found.10,11
Another finding from the new analysis was that a large number of major ischemic events, and hence a large number of the events prevented by DAPT, occurred in the first 2 days following the index event, a finding made possible because the POINT investigators enrolled patients and started treatment within 12 hours of the qualifying events.
Conclusion: Atrial fibrillation was found with increased frequency in patients with acute ischemic stroke.
The variables comprised the demographic data of the patients such as sex, age, stroke subtype (ischemic or hemorrhagic), risk factors (hypertension, diabetes, hyperlipidemia, smoking habits, alcohol consumption, Atrial fibrillation (AF), oral contraceptive use, a history of previous transient ischemic attacks, cerebrovascular accidents (CVAs), acute coronary syndromes, familial predisposition), and the presence of central or peripheral vascular syndromes (strokes, limb arterial thrombosis, and mesenteric artery thrombosis).
IRB meets regularly and monitors the progress of Preventing Ischemic Cerebrovascular events in high-risk patients with acute Non-disabling Ischemic Cerebrovascular events using RIC (PICNIC-One) study to ensure that research ethics are met and every participant receives the highest standard of human protection.
Having stroke risk factors such as hypertension, ischemic heart disease, diabetes mellitus, hyperlipidemia, and smoking were also entered into the checklist.
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