During the first month after transplantation, natural isoagglutinin anti-A remained below 1/4 and immune isoagglutinin anti-A increased transiently to 1/16.
have reported a case of accelerated ABMR that occurred very early after ABOi KT, caused by a rebound in isoagglutinin levels .
Similar to previous published cases [8, 9, 16], in one of the two cases (case 2), a rebound (slight and delayed) in isoagglutinin level was observed.
In ABOI transplantation, removal or suppression of the antibody to the foreign blood group antigens (isoagglutinins) is the key to success.
In this protocol, plasmapheresis is used to remove isoagglutinins, and CMV-HG is used to prevent them from rebounding.